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Proteintech
SLC19A1 Polyclonal Antibody
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Product Details
25958-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SLC19A1 Fusion Protein Ag22921
Conjugate
Form
Liquid
Concentration
233 µg/mL
Amount
34.95 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
Transport of folate compounds into mammalian cells can occur via receptor-mediated or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cyclic dinucleotide:anion antiporter SLC19A1; folate transporter 1; Folate:anion antiporter SLC19A1; FOLT; hSLC19A1; IFC-1; Intestinal folate carrier 1; intestinal folate carrier protein; Placental folate transporter; Plasma membrane folate antiporter SLC19A1; Reduced folate carrier 1; Reduced folate carrier protein; Reduced folate transporter; Reduced folate transporter 1; RFC; RFC-1; RFT-1; solute carrier family 19 (folate transporter), member 1; solute carrier family 19 (sodium/hydrogen exchanger), member 1; Solute carrier family 19 member 1; unnamed protein product
Gene Aliases: AI323572; CHMD; FLOT1; FOLT; hRFC; hSLC19A1; IFC-1; IFC1; IMD114; MEGAF; REFC; RFC; RFC-1; RFC1; RFT-1; SLC19A1
UniProt ID: (Human) P41440, (Mouse) P41438
Entrez Gene ID: (Human) 6573, (Mouse) 20509
protein binding
folic acid binding
organic anion transmembrane transporter activity
folic acid transporter activity
reduced folate carrier activity
antiporter activity
methotrexate transporter activity
xenobiotic transporter activity
cyclic-GMP-AMP binding
vitamin transmembrane transporter activity
cyclic-GMP-AMP transmembrane transporter activity
transporter
drug transmembrane transport
female pregnancy
response to xenobiotic stimulus
response to toxic substance
organic anion transport
folic acid transport
folic acid metabolic process
vitamin transport
methotrexate transport
anion transmembrane transport
reduced folate transmembrane transport
cyclic-GMP-AMP transmembrane import across plasma membrane
positive regulation of cGAS/STING signaling pathway
transport across blood-brain barrier
folic acid import into cell
transport
transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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