Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter.
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Protein Aliases: 1-Oct; DKFZp313N1010; FLJ25043; FLJ37489; H oct1_cds; hOCT1; mOCT1; Organic cation transporter 1; rOCT1; solute carrier family 22 (organic cation transporter), member 1; Solute carrier family 22 member 1; solute carrier family 22, member 1; SYK
Gene Aliases: HOCT1; Lx1; OCT1; oct1_cds; Orct; Orct1; Roct1; SLC22A1
Molecular Function: secondary carrier transporter