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Proteintech
SLC22A18 Polyclonal Antibody
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Product Details
11646-2-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SLC22A18 Fusion Protein Ag2245 (17-424 aa encoded by BC015571)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
45 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSALGRSSV ILLTYVLAAT ELTCLFMQFS IVPYLSRKLG LDSIAFGYLQ TTFGVLQLLG GPVFGRFADQ RGARAALTLS FLAALALYLL LAAASSPALP GVYLLFASRL PGALMHTLPA AQMVITDLSA PEERPAALGR LGLCFGVGVI LGSLLGGTLV SAYGIQCPAI LAALATLLGA VLSFTCIPAS TKGAKTDAQA PLPGGPRASV FDLKAIASLL RLPDVPRIFL VKVASNCPTG LFMVMFSIIS MDFFQLEAAQ AGYLMSFFGL LQMVTQGLVI GQLSSHFSEE VLLRASVLVF IVVGLAMAWM SSVFHFCLLV PGLVFSLCTL NVVTDSMLIK AVSTSDTGTM LGLCASVQPL LRTLGPTVGG LLYRSFGVPV FGHVQVAINT LVLLVLWRKP MPQRKDKVR (17-424 aa encoded by BC015571)
Target Information
ORCTL2 (organic cation transporter-like protein 2), also known as HET, ITM, BWR1A, IMPT1, TSSC5, BWSCR1A, SLC22A1L, p45-BWR1A or SLC22A18, is a 424 amino acid multi-pass membrane protein that localizes at the apical membrane surface of renal proximal tubules. ORCTL2 is expressed at high levels in the kidney, liver, colon and in fetal renal proximal tubules and present at lower levels in heart, brain and lung. Belonging to the major facilitator superfamily, ORCTL2 may act as a transporter of organic cations based on a proton efflux antiport mechanism and may also play a role in the transport of chloroquine and quinidine-related compounds in kidney. Defects in ORCTL2 are associated with breast and lung cancer and are the cause of rhabdomyosarcoma type 1, a malignant tumor derived from striated muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein; Efflux transporter-like protein; imprinted multi-membrane spanning polyspecific transporter-related protein 1; imprinted multi-membrane-spanning polyspecific transporter-like gene 1; Imprinted multi-membrane-spanning polyspecific transporter-related protein 1; IMPT1 protein; integral membrane transport protein; Multi-membrane-spanning polyspecific transporter; ORCTL-2; Organic cation transporter-like protein 2; organic cationic transporter-like 2; p45 Beckwith-Wiedemann region 1A; p45-Beckwith-Wiedemann region 1 A; p45-BWR1A; putative membrane protein channel; solute carrier family 22 (organic cation transporter), member 18; Solute carrier family 22 member 1-like; Solute carrier family 22 member 18; Solute carrier family 67 member A1; TSSC5p; tumor suppressing subtransferable candidate 5; Tumor-suppressing STF cDNA 5 protein; Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein
Gene Aliases: AW260131; BWR1A; BWSCR1A; HET; IMPT1; ITM; ORCTL2; p45-BWR1A; SLC22A18; SLC22A1L; SLC67A1; TSSC5
UniProt ID: (Human) Q96BI1, (Mouse) Q78KK3, (Rat) Q6AY78
Entrez Gene ID: (Human) 5002, (Mouse) 18400, (Rat) 309131
protein binding
transmembrane transporter activity
ubiquitin protein ligase binding
xenobiotic transporter activity
transporter activity
organic anion transmembrane transporter activity
drug transmembrane transporter activity
symporter activity
molecular_function
transporter
secondary carrier transporter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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