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Invitrogen
SLC22A2 Polyclonal Antibody
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Product Details
PA5-37290
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
C. elegans,
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to residues in human SLC22A2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 100 kDa.
Purity is >95% by SDS-PAGE.
Target Information
Organic cation transporters (OCT) are expressed in the plasma membrane of epithelial cells from a wide range of tissues, where they function in the elimination of endogenous amines, cationic drugs and other xenobiotics. The structure of OCTs consists of a 12-transmembrane-domain structure and a large extracellular hydrophilic loop. In humans, OCT1 is primarily expressed in the liver, while OCT2 is expressed in the kidney. OCT3 is expressed in the placenta, skeletal muscle, prostate, aorta and liver. OCT2, also known as SLC22A2, is a multi-specific transporter protein localizing to the basolateral and luminal membranes of the kidney distal tubule and proximal tubules. OCT2 is responsible for mediating the pH-sensitive tubular uptake of organic compounds from circulation. An additional splice variant exists for OCT2, namely OCT2-A.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 2-Oct; hOCT2; mOCT2; Organic cation transporter 2; rOCT2; solute carrier family 22 (organic cation transporter), member 2; Solute carrier family 22 member 2; solute carrier family 22, member 2
Gene Aliases: OCT2; OCT2r; Orct2; rOCT2; SLC22A2
UniProt ID: (Human) O15244, (Rat) Q9R0W2, (Mouse) O70577
Entrez Gene ID: (Human) 6582, (Rat) 29503, (Mouse) 20518
neurotransmitter transporter activity
dopamine transmembrane transporter activity
steroid binding
organic cation transmembrane transporter activity
choline transmembrane transporter activity
quaternary ammonium group transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
transmembrane transporter activity
secondary carrier transporter
drug transmembrane transport
neurotransmitter secretion
body fluid secretion
organic cation transport
quaternary ammonium group transport
choline transport
dopamine transport
neurotransmitter biosynthetic process
histamine transport
cation transport
ion transmembrane transport
cation transmembrane transport
transport
ion transport
transmembrane transport
ammonium transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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