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Product Details
PA5-97062
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 44-140 of human SLC22A2.
Conjugate
Unconjugated
Form
Liquid
Concentration
1.49 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2808864
Product Specific Information
Immunogen sequence: GFTPDHRCRS PGVAELSLRC GWSPAEELNY TVPGPGPAGE ASPRQCRRYE VDWNQSTFDC VDPLASLDTN RSRLPLGPCR DGWVYETPGS SIVTEFN; Positive Samples: Rat brain; Cellular Location: Membrane, Multi-pass membrane protein
Target Information
Organic cation transporters (OCT) are expressed in the plasma membrane of epithelial cells from a wide range of tissues, where they function in the elimination of endogenous amines, cationic drugs and other xenobiotics. The structure of OCTs consists of a 12-transmembrane-domain structure and a large extracellular hydrophilic loop. In humans, OCT1 is primarily expressed in the liver, while OCT2 is expressed in the kidney. OCT3 is expressed in the placenta, skeletal muscle, prostate, aorta and liver. OCT2, also known as SLC22A2, is a multi-specific transporter protein localizing to the basolateral and luminal membranes of the kidney distal tubule and proximal tubules. OCT2 is responsible for mediating the pH-sensitive tubular uptake of organic compounds from circulation. An additional splice variant exists for OCT2, namely OCT2-A.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2-Oct; hOCT2; Organic cation transporter 2; rOCT2; solute carrier family 22 (organic cation transporter), member 2; Solute carrier family 22 member 2; solute carrier family 22, member 2
Gene Aliases: OCT2; OCT2r; rOCT2; SLC22A2
UniProt ID: (Human) Q5T7Q6, (Rat) Q9R0W2
Entrez Gene ID: (Human) 6582, (Rat) 29503
Molecular Function:
secondary carrier transporter
drug transmembrane transport
neurotransmitter secretion
body fluid secretion
organic cation transport
quaternary ammonium group transport
choline transport
dopamine transport
neurotransmitter biosynthetic process
histamine transport
cation transport
ion transmembrane transport
cation transmembrane transport
Performance Guarantee
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