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Invitrogen
SLC22A4 Polyclonal Antibody
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FIGURE: 1 / 1
SLC22A4 Antibody (PA5-87939) in WB
Western blot analysis of SLC22A4 in extracts of various cell lines. Samples were incubated with SLC22A4 Polyclonal antibody (Product # PA5-87939) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
PA5-87939
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
1.74 mg/mL
Amount
174 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: SW480, HL-60, NCI-H460, LO2, HeLa, Mouse kidney, Mouse liver, Rat liver; Cellular Location: Membrane, Multi-pass membrane protein
Target Information
Carnitine (b-hydroxy-g-trimethylaminobutyrate) is a small, highly polar compound that aids in the b-oxidation of long-chain fatty acids. Organic cation/carnitine transporters (OCTN) assist in the elimination of cationic compounds, including xenobiotics, and transport carnitine for reabsorption in the kidney. Similar to organic cation transporters (OCT), OCTN proteins localize to the plasma membrane of epithelial cells. OCTN1 is expressed in kidney, trachea, bone marrow and fetal liver. OCTN2 is abundantly expressed in kidney, skeletal muscle, placenta and heart. OCTN3 is strongly expressed in testis and weakly expressed in kidney. The gene encoding human OCTN1 maps to chromosome 5 and the gene encoding human OCTN2 maps to chromosome 5q31. Mutations in the gene encoding OCTN2 leads to systemic carnitine deficiency (SCD), an autosomal recessive disorder characterized by cardiomyopathy, skeletal myopathy, lethargy, hypoglycemia and hyperammonemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: deafness, autosomal recessive 60; Ergothioneine transporter; ET transporter; integral membrane transport protein; LSTP-Like 2; OCTN1; organic cation transporter 1; organic cation transporter OCTN1; Organic cation/carnitine transporter 1; solute carrier family (organic cation transporter), member 4; solute carrier family 22 (organic cation transporter), member 4; solute carrier family 22 (organic cation/ergothioneine transporter), member 4; solute carrier family 22 (organic cation/zwitterion transporter), member 4; Solute carrier family 22 member 4
Gene Aliases: DFNB60; ETT; ETTh; OCTN1; SLC22A4; UT2H
UniProt ID: (Human) Q9H015, (Rat) Q9R141, (Mouse) Q9Z306
Entrez Gene ID: (Human) 6583, (Rat) 64037, (Mouse) 30805
nucleotide binding
acetylcholine transmembrane transporter activity
protein binding
ATP binding
secondary active organic cation transmembrane transporter activity
organic cation transmembrane transporter activity
amino acid transmembrane transporter activity
amino-acid betaine transmembrane transporter activity
carnitine transmembrane transporter activity
symporter activity
quaternary ammonium group transmembrane transporter activity
transmembrane transporter activity
PDZ domain binding
cation:cation antiporter activity
transporter activity
ion transmembrane transporter activity
secondary carrier transporter
sulfur amino acid transport
triglyceride metabolic process
ion transport
sodium ion transport
neurotransmitter transport
lactation
carnitine metabolic process
quaternary ammonium group transport
carnitine transport
response to lipopolysaccharide
response to vitamin D
xenobiotic transport
response to exogenous dsRNA
acetylcholine uptake
transmembrane transport
amino acid import across plasma membrane
liver regeneration
carnitine transmembrane transport
amino acid transmembrane transport
organic cation transport
ion transmembrane transport
modified amino acid transport
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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