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Invitrogen
SLC22A5 Polyclonal Antibody
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FIGURE: 1 / 1
SLC22A5 Antibody (PA5-80016) in WB
Western blot analysis of SLC22A5 in Lane 1: rat kidney tissue lysate, Lane 2: rat skeletal muscles tissue lysate, Lane 3: mouse liver tissue lysate, Lane 4: HEPA cell lysate, Lane 5: NIH3T3 cell lysate. Sample was incubated with SLC22A5 polyclonal antibody (Product # PA5-80016).
Product Details
PA5-80016
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of mouse Solute carrier family 22 member 5 (531-547aa KQWQIQSQTRMQKDGEE).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide, 0.05mg thimerosal
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: Rat Kidney Tissue, Rat Skeletal Muscles Tissue, Mouse Liver Tissue, HEPA Cell, NIH3T3 Cell.
Target Information
Carnitine (b-hydroxy-g-trimethylaminobutyrate) is a small, highly polar compound that aids in the b-oxidation of long-chain fatty acids. Organic cation/carnitine transporters (OCTN) assist in the elimination of cationic compounds, including xenobiotics, and transport carnitine for reabsorption in the kidney. Similar to organic cation transporters (OCT), OCTN proteins localize to the plasma membrane of epithelial cells. OCTN1 is expressed in kidney, trachea, bone marrow and fetal liver. OCTN2 is abundantly expressed in kidney, skeletal muscle, placenta and heart. OCTN3 is strongly expressed in testis and weakly expressed in kidney. The gene encoding human OCTN1 maps to chromosome 5 and the gene encoding human OCTN2 maps to chromosome 5q31. Mutations in the gene encoding OCTN2 leads to systemic carnitine deficiency (SCD), an autosomal recessive disorder characterized by cardiomyopathy, skeletal myopathy, lethargy, hypoglycemia and hyperammonemia.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CT1; high-affinity carnitine transporter; High-affinity sodium-dependent carnitine cotransporter; integral membrane transport protein; juvenile visceral steatosis; OCTN2VT; Organic cation/carnitine transporter 2; S22A5; solute carrier family 22 (organic cation transporter), member 5; Solute carrier family 22 member 5; solute carrier family 22, member 5; UST2r
Gene Aliases: CT1; jvs; Lstpl; OCTN2; Slc22a5; UST2r
UniProt ID: (Mouse) Q9Z0E8, (Rat) O70594
Entrez Gene ID: (Mouse) 20520, (Rat) 29726
nucleotide binding
transporter activity
ATP binding
ion transmembrane transporter activity
carnitine transmembrane transporter activity
symporter activity
quaternary ammonium group transmembrane transporter activity
transmembrane transporter activity
PDZ domain binding
antibiotic transporter activity
protein binding
cation:cation antiporter activity
secondary carrier transporter
transport
ion transport
sodium ion transport
mitochondrion organization
adult heart development
locomotory behavior
carnitine metabolic process
organic cation transport
quaternary ammonium group transport
carnitine transport
ion transmembrane transport
antibiotic transport
reproductive structure development
quorum sensing involved in interaction with host
transmembrane transport
positive regulation of intestinal epithelial structure maintenance
sodium-dependent organic cation transport
modified amino acid transport
carnitine transmembrane transport
amino acid transmembrane transport
triglyceride metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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