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SLC24A6 Polyclonal Antibody

SLC24A6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SLC24A6 Antibody (21430-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using (Product # 21430-1-AP) (SLC24A6 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

21430-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:300-1:1,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

Assay-dependent

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SLC24A6 Fusion Protein Ag16034 (240-333 aa encoded by BC098360)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: YVVTVILCT WIYQRQRRGS LFCPMPVTPE ILSDSEEDRV SSNTNSYDYG DEYRPLFFYQ ETTAQILVRA LNPLDYMKWR RKSAYWKALK VFKLP (240-333 aa encoded by BC098360)

Target Information

SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic counter transport of 4 sodium ions for 1 calcium ion and 1 potassium ion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The effect of regulating MCU expression on experimental ischemic brain injury.

Experimental neurology

Qin J,Liu L,Liu L,Zhou Z,Zhou Y,Zhang K,Wang B,Lu H,Ran J,Ma T,Zhang Y,Li Z,Liu X

Sat Apr 01 00:00:00 UTC 2023

Lon upregulation contributes to cisplatin resistance by triggering NCLX-mediated mitochondrial Ca²⁺ release in cancer cells.

Cell death & disease

Tangeda V,Lo YK,Babuharisankar AP,Chou HY,Kuo CL,Kao YH,Lee AY,Chang JY

Wed Mar 16 00:00:00 UTC 2022

Lon upregulation contributes to cisplatin resistance by triggering NCLX-mediated mitochondrial Ca²⁺ release in cancer cells.

Cell death & disease

Tangeda V,Lo YK,Babuharisankar AP,Chou HY,Kuo CL,Kao YH,Lee AY,Chang JY

Wed Mar 16 00:00:00 UTC 2022

CD137 Signal Mediates Cardiac Ischemia-Reperfusion Injury by Regulating the Necrosis of Cardiomyocytes.

Journal of cardiovascular translational research

Xu Y,Chen R,Yan J,Zang G,Shao C,Wang Z

Sat Oct 01 00:00:00 UTC 2022

Astragalus Polysaccharides Reduce High-glucose-induced Rat Aortic Endothelial Cell Senescence and Inflammasome Activation by Modulating the Mitochondrial Na⁺/Ca²⁺ Exchanger.

Cell biochemistry and biophysics

Miao XY,Zhu XX,Gu ZY,Fu B,Cui SY,Zu Y,Rong LJ,Hu F,Chen XM,Gong YP,Li CL

Wed Jun 01 00:00:00 UTC 2022

Astragalus Polysaccharides Reduce High-glucose-induced Rat Aortic Endothelial Cell Senescence and Inflammasome Activation by Modulating the Mitochondrial Na⁺/Ca²⁺ Exchanger.

Cell biochemistry and biophysics

Miao XY,Zhu XX,Gu ZY,Fu B,Cui SY,Zu Y,Rong LJ,Hu F,Chen XM,Gong YP,Li CL

Wed Jun 01 00:00:00 UTC 2022

The mitochondrial Na(+)/Ca(2+) exchanger may reduce high glucose-induced oxidative stress and nucleotide-binding oligomerization domain receptor 3 inflammasome activation in endothelial cells.

Journal of geriatric cardiology : JGC

Zu Y,Wan LJ,Cui SY,Gong YP,Li CL

Fri May 01 00:00:00 UTC 2015

The mitochondrial Na(+)/Ca(2+) exchanger may reduce high glucose-induced oxidative stress and nucleotide-binding oligomerization domain receptor 3 inflammasome activation in endothelial cells.

Journal of geriatric cardiology : JGC

Zu Y,Wan LJ,Cui SY,Gong YP,Li CL

Fri May 01 00:00:00 UTC 2015

The mitochondrial Na(+)/Ca(2+) exchanger may reduce high glucose-induced oxidative stress and nucleotide-binding oligomerization domain receptor 3 inflammasome activation in endothelial cells.

Journal of geriatric cardiology : JGC

Zu Y,Wan LJ,Cui SY,Gong YP,Li CL

Fri May 01 00:00:00 UTC 2015

The mitochondrial Na(+)/Ca(2+) exchanger may reduce high glucose-induced oxidative stress and nucleotide-binding oligomerization domain receptor 3 inflammasome activation in endothelial cells.

Journal of geriatric cardiology : JGC

Zu Y,Wan LJ,Cui SY,Gong YP,Li CL

Fri May 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: Mitochondrial sodium/calcium exchanger protein; Na(+)/K(+)/Ca(2+)-exchange protein 6; Sodium/calcium exchanger protein, mitochondrial; Sodium/potassium/calcium exchanger 6; sodium/potassium/calcium exchanger 6, mitochondrial; solute carrier family 24 (sodium/lithium/calcium exchanger), member 6; solute carrier family 24 (sodium/potassium/calcium exchanger), member 6; Solute carrier family 24 member 6; solute carrier family 8 (sodium/lithium/calcium exchanger), member B1; Solute carrier family 8 member B1

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Gene Aliases: AF261233; NCKX6; NCLX; SLC24A6; SLC8B1

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UniProt ID: (Human) Q6J4K2, (Mouse) Q925Q3

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Entrez Gene ID: (Human) 80024, (Mouse) 170756

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Function(s)

calcium:sodium antiporter activity calcium:cation antiporter activity protein homodimerization activity calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential antiporter activity identical protein binding primary active transporter

Process(es)

ion transport mitochondrial calcium ion transport sodium ion transmembrane transport glucose homeostasis regulation of insulin secretion response to stimulus regulation of cytosolic calcium ion concentration mitochondrial calcium ion homeostasis calcium ion transmembrane transport regulation of cardiac muscle cell membrane potential transport sodium ion transport calcium ion transport transmembrane transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SLC24A6 Polyclonal Antibody

SLC24A6 Antibody (21430-1-AP) in IHC (P)

Product Details

21430-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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