This protein encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response.
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Protein Aliases: 34 kDa peroxisomal membrane protein; peroxisomal integral membrane protein 47; Peroxisomal membrane protein PMP34; peroxisomal membrane protein, 34 kDa; solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17; Solute carrier family 25 member 17; solute carrier family 25, member 17
Gene Aliases: 34kDa; 47kDa; PMP34; Pmp35; Pmp47; SLC25A17