Immunogen sequence: AAVSKTAVAPI ERVKLLLQVQ HASKQIS
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.
Adenine nucleotide translocator (ANT) and the voltage-dependent anion-selective channel proteins 1 and 2 (VDAC1 and VDAC2) are components of the permeability transition pore complex (PTPC) of the mitochondrial inner and outer membranes, respectively. Formation of PTPCs, the subsequent dissipation of mitochondrial inner membrane potential and release of cytochrome c through the outer mitochondrial membrane are critical events in the early stages of apoptosis. Bax, a proapoptotic protein, has been shown to act upon ANT to induce the dissipation of mitochondrial inner membrane potential. ANT1 has a role in the maintenance of mitochondrial DNA by catalyzing the exchange of ADP and ATP across the mitochondrial inner membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Adenine nucleotide translocator 2; adenine nucleotide translocator 2 (fibroblast); ADP,ATP carrier protein 2; ADP,ATP carrier protein, fibroblast isoform; ADP/ATP translocase 2; ADP/ATP translocase 2, N-terminally processed; ANT 2; ANT2; ATP carrier protein; ATP carrier protein 2; DP/ATP translocase 2; fibroblast isoform; N-terminally processed; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5; Solute carrier family 25 member 5
Gene Aliases: 2F1; AAC2; ANT2; SLC25A5; T2; T3
UniProt ID: (Human) P05141
Entrez Gene ID: (Human) 292
Molecular Function: RNA binding protein amino acid transporter calcium-binding protein calmodulin intracellular calcium-sensing protein mitochondrial carrier protein nucleic acid binding ribosomal protein transfer/carrier protein transporter