The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
ANT2 (adenine nucleotide translocator 2), also known as SLC25A5 (solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5), T2, T3, 2F1 or AAC2, is a 298 amino acid multi-pass membrane protein that localizes to the inner mitochondrial membrane and contains three solcar repeats. Existing as one of the most abundant mitochondrial proteins, ANT2 functions as a homodimer that facilitates the exchange of ADP and ATP between the mitochondrion and the cytosol, thus linking the compartment of ATP production (within the mitochondrion) to the areas of ATP utilization (within the cytosol). Suppression of ANT2 in breast cancer cells results in apoptosis and tumor growth inhibition, suggesting that ANT2 may be involved in carcinogenesis. ANT3 (adenine nucleotide translocator 2) is a 298 amino acid mitochondrial protein that functions in a similar manner to ANT2 but, unlike ANT2, may also play a role in the formation of the permeability transition pore complex (PTPC), a structure that is important for the regulation of apoptosis.
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Protein Aliases: Adenine nucleotide translocator 3; ADP,ATP carrier protein 3; ADP,ATP carrier protein, isoform T2; ADP,ATP carrier protein, liver; ADP/ATP translocase 3; ADP/ATP translocase 3, N-terminally processed; ADP/ATP translocator of liver; ANT 2; ANT 3; ANT3; ORF Names: CDABP0051; SLC25A6; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6; Solute carrier family 25 member 6
Gene Aliases: AAC3; ANT; ANT 2; ANT 3; ANT3; ANT3Y; CDABP0051; SLC25A6
UniProt ID: (Human) P12236
Entrez Gene ID: (Human) 293
Molecular Function: RNA binding protein amino acid transporter calcium-binding protein calmodulin intracellular calcium-sensing protein mitochondrial carrier protein nucleic acid binding ribosomal protein transfer/carrier protein transporter