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Proteintech
SLC26A5 Polyclonal Antibody
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Product Details
22013-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SLC26A5 fusion protein Ag16631
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
60 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MDHAEENEIL AATQRYYVER PIFSHPVLQE RLHTKDKVPD SIADKLKQAF TCTPKKIRNI IYMFLPITKW LPAYKFKEYV LGDLVS
Target Information
SLC26A5 is a member of the SLC26A/SulP transporter family. SLC26A5 is specifically expressed in outer hair cells (OHCs) of the cochlea and is essential in auditory processing. Intracellular anions are thought to act as extrinsic voltage sensors, which bind to this protein and trigger the conformational changes required for rapid length changes in OHCs. Mutations in its gene have been associated with non-syndromic hearing loss.This gene is a member of the SLC26A/SulP transporter family. It encodes a protein that is specifically expressed in outer hair cells (OHCs) of the cochlea and is essential in auditory processing. Intracellular anions are thought to act as extrinsic voltage sensors, which bind to this protein and trigger the conformational changes required for rapid length changes in OHCs. Mutations in this gene have been associated with non-syndromic hearing loss. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cochlear motor protein; MGC118886; MGC118887; MGC118888; MGC118889; molecular motor; putative anion exchanger; motor protein; outer hair cell motor protein; Prestin; prestin (motor protein); solute carrier family 26 (anion exchanger), member 5; Solute carrier family 26 member 5; solute carrier family 26, member 5 (prestin)
Gene Aliases: DFNB61; PRES; prestin; SLC26A5
UniProt ID: (Human) P58743, (Mouse) Q99NH7, (Rat) Q9EPH0
Entrez Gene ID: (Human) 375611, (Mouse) 80979, (Rat) 83819
protein binding
secondary active sulfate transmembrane transporter activity
sulfate transmembrane transporter activity
oxalate transmembrane transporter activity
spectrin binding
identical protein binding
protein homodimerization activity
chloride:bicarbonate antiporter activity
transcription factor binding
motor activity
transporter
response to ischemia
chloride transport
sensory perception of sound
regulation of cell shape
response to xenobiotic stimulus
response to salicylic acid
response to auditory stimulus
bicarbonate transport
fructose transport
oxalate transport
ion transmembrane transport
negative regulation of ion transmembrane transport
response to potassium ion
regulation of membrane potential
positive regulation of cell size
transmembrane transport
cochlea development
response to thyroid hormone
anion transmembrane transport
response to salt
sulfate transmembrane transport
chloride transmembrane transport
positive regulation of cell motility
sulfate transport
protein tetramerization
metabolic process
response to drug
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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