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Proteintech
SLC26A7 Polyclonal Antibody
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Product Details
17654-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SLC26A7 fusion protein Ag11901
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: IAIVIGRFPR AMTVSIKNMK EMEFKVKTEM DSETLQQVKI ISINNPLVFL NAKKFYTDLM NMIQKENACN QPLDDISKCE QNTLLNSLSN GNCNEEASQS CPNEKCYLIL DCSGFTFFDY SGVSMLVEVY MDCKGRSVDV LLAHCTASLI KAMTYYGNLD SEKPIFFESV SAAISHIHSN KNLSKLSDHS EV
Target Information
SLC26A7 (solute carrier family 26 member 7) is a chloride-base exchanger and/or chloride transporter that is expressed on basolateral membrane of acid-secreting cells in renal outer medullary collecting duct (OMCD) and in gastric parietal cells also. SLC26A7 belongs to conserved family of anion transporters SLC26 isoforms which display tissue-specific expression patterns in epithelial cells and several SLC26 members function as chloride/bicarbonate exchangers that include SLC26A3 (DRA), SLC26A4 (pendrin), SLC26A6 (PAT1 or CFEX), SLC26A7, and SLC26A9 among which SLC26A7 and SLC26A9 also function as chloride channels. In renal tissues, Slc26a7 co-localizes with AE1, a well-known Cl-/HCO3- exchanger, on the basolateral membrane of (acid-secreting) A-intercalated cells in OMCD cells, and in the gastric tissue, SLC26A7 co-localizes with AE2, a major Cl-/HCO3- exchanger, on the basolateral membrane of acid secreting parietal cells. SLC26A7 acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. SLC26A7 maintains the electrolyte/acid-base homeostasis in kidneys by acting as a distal excretory segment-specific anion exchanger, specifically chloride, and plays a major role in gastric acid secretion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Anion exchange transporter; anion exchanger Slc26a7; MGC30955; RP23-272I16.1; SLC26A7; solute carrier family 26 (anion exchanger), member 7; Solute carrier family 26 member 7; solute carrier family 26, member 7; sulfate anion transporter
Gene Aliases: SLC26A7; SUT2
UniProt ID: (Human) Q8TE54, (Mouse) Q8R2Z3
Entrez Gene ID: (Human) 115111, (Rat) 297910, (Mouse) 208890
chloride channel activity
secondary active sulfate transmembrane transporter activity
bicarbonate transmembrane transporter activity
sulfate transmembrane transporter activity
anion:anion antiporter activity
oxalate transmembrane transporter activity
anion channel activity
anion transmembrane transporter activity
transporter
gastric acid secretion
ion transport
anion transport
chloride transport
sulfate transport
bicarbonate transport
oxalate transport
regulation of membrane potential
regulation of intracellular pH
sulfate transmembrane transport
chloride transmembrane transport
inorganic anion transport
ion transmembrane transport
transport
transmembrane transport
anion transmembrane transport
organic acid transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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