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Invitrogen
SLC28A2 Polyclonal Antibody
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FIGURE: 1 / 3
SLC28A2 Antibody (PA5-101897) in ICC/IF
Immunofluorescent analysis of SLC28A2 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and SLC28A2 polyclonal antibody (Product # PA5-101897) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
Product Details
PA5-101897
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SLC28A2(Accession O43868), corresponding to amino acid residues C372-N422.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total SLC28A2.
Target Information
The concentrative nucleoside transporter (CNT) family comprises three members: CNT1, CNT2 and CNT3. CNT2 participates in the absorption and disposition of endogenous nucleosides and mediates the first step of nucleotide biosynthesis. CNT2 levels are highly dependent on insulin (but not glucose) concentration, and the protein is under the control of the Adenosine 1 receptor. CNT family members are imperative in the response of cells to a variety of anticancer and antiviral nucleoside analogs, as the CNT proteins modulate their entry into target tissues. Increasing evidence also suggests that CNT2 may have a role in energy metabolism because activation of CNT2 relies on the opening of ATP-sensitive K+ channels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CNT 2; CNT-2; Concentrative nucleoside transporter 2; Na(+)/nucleoside cotransporter 2; purine-selective Na+ nucleoside cotransporter; rCNT2; Sodium-coupled nucleoside transporter 2; Sodium/nucleoside cotransporter 2; Sodium/purine nucleoside co-transporter; Sodium/purine nucleoside cotransporter; solute carrier family 28 (concentrative nucleoside transporter), member 2; solute carrier family 28 (sodium-coupled nucleoside transporter), member 2; Solute carrier family 28 member 2; solute carrier family 28, member 2; SPNT; unnamed protein product
Gene Aliases: 2010208B10Rik; B430217P18; BB152493; CNT2; HCNT2; HsT17153; SLC28A2; Spnt; SPNT1
UniProt ID: (Human) O43868, (Mouse) O88627, (Rat) Q62773
Entrez Gene ID: (Human) 9153, (Mouse) 269346, (Rat) 60423
neurotransmitter transporter activity
nucleoside transmembrane transporter activity
purine nucleobase transmembrane transporter activity
nucleoside:sodium symporter activity
purine nucleoside transmembrane transporter activity
uridine transmembrane transporter activity
pyrimidine- and adenine-specific:sodium symporter activity
azole transmembrane transporter activity
nucleoside binding
transporter
retina homeostasis
nucleobase-containing compound metabolic process
xenobiotic metabolic process
neurotransmitter transport
drug transmembrane transport
pyrimidine nucleobase transport
purine nucleoside transmembrane transport
uridine transport
adenosine transport
inosine transport
azole transport
pyrimidine-containing compound transmembrane transport
transport across blood-brain barrier
nucleoside transmembrane transport
purine nucleobase transmembrane transport
transport
protein localization to cell surface
sodium ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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