Immunogen sequence: LHTAEYLTYY GAFFLYAGFA AVGLLFIYGC LPETKGKKLE EIESLFDNRL CTCGTSDSDE GRYIEYIRVK GSNYHLSDND ASDVE; Positive Samples: HeLa, SH-SY5Y, HepG2, NCI-H460, HT-1080, K-562, Mouse kidney, Mouse pancreas, Rat kidney; Cellular Location: Membrane, Multi-pass membrane protein
SLC2A13 (solute carrier family 2 (facilitated glucose transporter), member 13) is a 648 multi-pass membrane protein that belongs to the major facilitator superfamily and the sugar transporter family. SLC2A13 is a H+-myo-inositol cotransporter that can also transport related stereoisomers. Human SLC2A13 shares 90% identity with its rat homolog. The rat sequence has 12 transmembrane domains, 3 N-glycosylation sites, several motifs important for glucose transport activity, and an endoplasmic reticulum retention signal and dileucine internalization signal in the N-terminal region. SLC2A13 has been shown to specifically transport myoinositol but not hexoses, and decreasing the pH of the extracellular medium from 7.0 to 5.0 markedly increased transport activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: H(+)-myo-inositol cotransporter; H(+)-myo-inositol symporter; hmit; proton (H+) myo-inositol symporter; Proton myo-inositol cotransporter; proton myo-inositol symporter; solute carrier family 2 (facilitated glucose transporter), member 13; Solute carrier family 2 member 13
Gene Aliases: 6530403A04; A630029G22Rik; AI505012; Gm308; HMIT; SLC2A13
Molecular Function: carbohydrate transporter