Renal tubular reabsorption of phosphate is critical to the maintenance of phosphate homeostasis in mammals. The brush-border membrane Na+/Pi cotransport systems in proximal tubules play a major role in this process. The renal Na(+)/P(i) cotransporter NPT2 is expressed in the brush border membrane (BBM) of proximal tubular cells. NPT2 gene expression is crucial for PTH effects on renal P(i) handling. However, renal expression of the sodium/phosphate cotransporter gene, NPT2, is not required for regulation of renal 1 alpha-hydroxylase by phosphate. NPT2 is an integral membrane protein expressed in kidney and lung. The gene encoding human NPT1 maps to chromosome 6q21.3-p23, while the gene encoding human NPT2 maps to chromosome 5q35.
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Protein Aliases: Na(+)-dependent phosphate cotransporter 2A; Na(+)/Pi cotransporter 2A; Na+-phosphate cotransporter type II; Na/Pi cotransporter; naPi-2a; NaPi-3; naPi-7; renal Na+/Pi transporter; renal sodium-dependent phosphate transporter; Sodium-dependent phosphate transport protein 2A; Sodium-phosphate transport protein 2A; sodium/phosphate co-transporter; Sodium/phosphate cotransporter 2A; solute carrier family 17 (sodium phosphate), member 2; solute carrier family 17 (sodium/hydrogen exchanger), member 2; solute carrier family 34 (sodium phosphate), member 1; solute carrier family 34 (type II sodium/phosphate cotransporter), member 1; Solute carrier family 34 member 1; type IIa Na+/Pi-cotransporter
Gene Aliases: FRTS2; HCINF2; NAPI-3; NaPi-IIa; NPHLOP1; NPT2; Npt2a; NPTIIa; SLC11; SLC17A2; SLC34A1
UniProt ID: (Human) Q06495
Molecular Function: secondary carrier transporter