Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: fringe connection; HFRC1; Homolog of Fringe connection protein 1; solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2; Solute carrier family 35 member D2; solute carrier family 35, member D2; SQV7-like protein; SQV7L; UDP-galactose transporter-related protein 8; UDP-N-acetylglucosamine transporter; UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter; UGTrel8
Gene Aliases: HFRC; HFRC1; SLC35D2; SQV7L; UGTREL8
UniProt ID: (Human) Q76EJ3
Entrez Gene ID: (Human) 11046
Molecular Function: transporter