The Slc37 gene family consists of four members which have 10-12 predicted transmembrane domains and belong to the sugar-phosphate transporter superfamily. Recent experiments have demonstrated that Slc37A2 is a macrophage-specific gene selectively expressed in obese white adipose tissue. Its transcript is also expressed in spleen and thymus and the cell lines RAW264.7 and THP-1. Compared to wild-type mice, Slc37A2 mRNA is expressed at nine-fold higher levels in abdominal epididymal fat deposits of ob/ob mice, suggesting that it may be required to limit the contribution of macrophages to the inflammatory state present in obesity. Slc37A2 protein is post-translationally modified with the addition of N-linked glycans and migrates as a heterogeneous species of 50-75 kDa.
Protein Aliases: cAMP inducible 2 protein; cAMP inducible gene 2; cAMP-inducible protein 2; Glucose-6-phosphate exchanger SLC37A2; solute carrier family 37 (glucose-6-phosphate transporter), member 2; solute carrier family 37 (glycerol-3-phosphate transporter), member 1; solute carrier family 37 (glycerol-3-phosphate transporter), member 2; Solute carrier family 37 member 2; sugar phosphate exchanger 2
Gene Aliases: cI-2; Ci2; G3PP; pp11662; RGD1564160; Slc37a1; SLC37A2
Molecular Function: transporter