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Immunogen sequence: RHGLLLFMMA GMTVSMYLFR VTVTSDSPKL WILVLGAVFG FSSYGPIALF GVIANESAPP NLCGTSHAIV GLMANVGGFL AGLPFSTIAK HYSWSTAFWV AEVICAASTA AFFLLRNIRT KMGRVSKKAE; Positive Samples: Mouse kidney, Rat liver; Cellular Location: Endoplasmic reticulum membrane, Multi-pass membrane protein
SLC37A4 transports glucose-6-phosphate from the cytoplasm to the lumen of the endoplasmic reticulum. It forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels.
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Protein Aliases: glucose 6-phosphate transporter; Glucose-5-phosphate transporter; glucose-6-phosphatase transport protein 1; glucose-6-phosphatase, transport (glucose) protein 3; glucose-6-phosphatase, transport (glucose-6-phosphate) protein 1; glucose-6-phosphatase, transport (phosphate/pyrophosphate) protein 2; glucose-6-phosphatase, transport protein 1; Glucose-6-phosphate exchanger SLC37A4; Glucose-6-phosphate translocase; MGC15729; microsomal glucose-6-phosphate transporter; solute carrier family 37 (glucose-6-phosphate transporter), member 4; solute carrier family 37 (glycerol-6-phosphate transporter), member 4; Solute carrier family 37 member 4; Transformation-related gene 19 protein; transporter; TRG-19
Gene Aliases: G6PT; G6PT1; G6PT2; G6PT3; GSD-1b; GSD1b; GSD1c; GSD1d; mG6PT; PRO0685; SLC37A4; TRG-19; TRG19
UniProt ID: (Human) O43826
Molecular Function: primary active transporter