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Invitrogen
SLC38A3 Polyclonal Antibody
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FIGURE: 1 / 1
SLC38A3 Antibody (PA5-92228) in WB
Western blot analysis of SLC38A3 in extracts of various cell lines. Samples were incubated with SLC38A3 Polyclonal antibody (Product # PA5-92228) followed by HRP Goat Anti-Rabbit IgG (H+L) secondary antibody at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Product Details
PA5-92228
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-65 of human SLC38A3 (NP_0068321)
Conjugate
Form
Liquid
Concentration
0.28 mg/mL
Amount
28 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MEAPLQTEMV ELVPNGKHSE GLLPVITPMA GNQRVEDPAR SCMEGKSFLQ KSPSKEPHFT DFEGK; Positive Samples: HeLa, Raji, Mouse brain; Cellular Location: Cell membrane, Multi-pass membrane protein
Target Information
As a sodium-dependent amino acid/proton antiporter, SLC38A3 mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. It also recognizes histidine, asparagine and alanine. It may mediate amino acid transport in either direction under physiological conditions and play a role in nitrogen metabolism and synaptic transmission.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hSN1; mNAT; N system amino acids transporter NAT-1; N-system amino acid transporter 1; Na(+)-coupled neutral amino acid transporter 3; SLC38A3; slc38a3 {ECO:0000312|RGD:628620}; Sodium-coupled neutral amino acid transporter 3; Solute carrier family 38 member 3; System N amino acid transporter 1; system N1 amino acid transporter; system N1 Na+ and H+-coupled glutamine transporter; unnamed protein product
Gene Aliases: 0610012J02Rik; D9Ucla2; DEE102; G17; mNAT; NAT1; Slc38-3; SLC38A3; SN1; SNAT3
UniProt ID: (Human) Q99624, (Rat) Q9JHZ9, (Mouse) Q9DCP2
Entrez Gene ID: (Human) 10991, (Rat) 252919, (Mouse) 76257
L-histidine transmembrane transporter activity
neutral amino acid:sodium symporter activity
amino acid transmembrane transporter activity
L-alanine transmembrane transporter activity
L-asparagine transmembrane transporter activity
L-glutamine transmembrane transporter activity
symporter activity
antiporter activity
L-glutamine, sodium:proton antiporter activity
L-asparagine, sodium:proton antiporter activity
L-histidine, sodium:proton antiporter activity
amino acid transporter
amino acid transmembrane transport
ion transport
sodium ion transport
amino acid transport
asparagine transport
glutamine transport
female pregnancy
glutamine secretion
L-alanine transport
histidine transport
positive regulation of transcription from RNA polymerase II promoter
cellular response to potassium ion starvation
amino acid homeostasis
transport across blood-brain barrier
L-histidine transport
L-glutamine import across plasma membrane
L-histidine import across plasma membrane
L-asparagine import across plasma membrane
positive regulation of glutamine transport
positive regulation of transcription from RNA polymerase II promoter in response to acidic pH
L-histidine transmembrane transport
transport
drug transmembrane transport
cation transmembrane transport
L-alpha-amino acid transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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