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SLC39A4 Polyclonal Antibody
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FIGURE: 1 / 2
SLC39A4 Antibody (BS-19832R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded Rat stomach; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with SLC39A4 Polyclonal Antibody, Unconjugated (bs-19832R) at 1:600 overnight at 4°C, DAB staining.
Product Details
BS-19832R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human SLC39A4, amino acids 281-380.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.03% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The zinc transporter ZIP4, also known as SLC39A4, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP4 was initially identified as zinc-uptake transporter in the intestine and as a candidate gene for acrodermatitis enteropathica (AE), a rare inherited defect in the absorption of dietary zinc. Similar to other ZIP family members, aberrant expression of ZIP4 has been linked to cancer, specifically the progression and aggressiveness of pancreatic cancer. ZIP4 expression has also been shown to be activated in hepatocellular carcinomas, acting to repress apoptosis, enhance cell cycle and increase migration, suggesting ZIP4 may play a role in multiple types of cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: slc39a4 {ECO:0000312|EMBL:AAI27515.1}; solute carrier family 39 (zinc transporter) member 4 isoform SLC39A4_1; solute carrier family 39 (zinc transporter) member 4 isoform SLC39A4_2; solute carrier family 39 (zinc transporter), member 4; Solute carrier family 39 member 4; unnamed protein product; zinc transporter 4; Zinc transporter ZIP4; ZIP-4; Zrt- and Irt-like protein 4; ZRT/IRT-like protein 4
Gene Aliases: AEZ; AWMS2; SLC39A4; ZIP4
UniProt ID: (Human) Q6P5W5, (Rat) A0JPN2
Entrez Gene ID: (Human) 55630, (Rat) 300051
zinc ion transmembrane transporter activity
zinc ion binding
identical protein binding
metal ion binding
metal ion transmembrane transporter activity
zinc ion sensor activity
monoatomic cation:bicarbonate symporter activity
zinc ion sequestering activity
molecular_function
secondary carrier transporter
ion transport
zinc II ion transport
cellular zinc ion homeostasis
bicarbonate transport
metal ion transport
cellular cation homeostasis
cellular response to zinc ion starvation
transmembrane transport
zinc II ion transmembrane transport
zinc II ion transmembrane import
biological_process
divalent inorganic cation transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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