The zinc transporter ZIP7, also known as SLC39A7, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP7 was initially identified while characterizing genes in the major histocompatibility complex on chromosome 17. ZIP7 mRNA is abundantly and widely expressed and the protein localizes to the Golgi apparatus. It functions to transport intracellular zinc from the Golgi apparatus to the cytoplasm of the cell. ZIP7 expression is expressed by zinc. ZIP7 has been suggested to act a hub for tyrosine kinase activation and may thus be a potential therapeutic target for diseases such as cancer where prevention of tyrosine kinase activation would be advantageous.
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Protein Aliases: DADB-100D22.3; H2-K region expressed gene 4; Histidine-rich membrane protein; Histidine-rich membrane protein Ke4; HLA class II region expressed gene KE4; Ke4 gene; Ke4 gene, mouse, human homolog of; Really interesting new gene 5 protein; RT1 class I, locus Ke4; RT1 region expressed gene KE4; solute carrier family 39 (zinc transporter), member 7; Solute carrier family 39 member 7; Zinc transporter SLC39A7; ZIP7; Zrt-, Irt-like protein 7
Gene Aliases: AA408174; AI117660; AL024048; D6S115E; D6S2244E; H-2Ke4; H2-KE4; HKE4; Ke-4; KE4; RING5; RT1-Ke4; Rt1Ke4; SLC39A7; ZIP7