A suggested positive control is human spleen tissue lysate.
PA5-21073 can be used with blocking peptide PEP-1187.
The zinc transporter ZIP8, also known as SLC39A9, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP8 is glycosylated and located at the plasma membrane and mitochondria. It has been identified as the transporter responsible for transport of the toxic Cadmium cation. ZIP8 has also been suggested to play a role in the regulation of interferon-gamma expression in activated human T cells.
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Protein Aliases: BCG induced integral membrane protein BIGM103; BCG-induced integral membrane protein in monocyte clone 103 protein; LIV-1 subfamily of ZIP zinc transporter 6; LZT-Hs6; solute carrier family 39 (metal ion transporter), member 8; Solute carrier family 39 member 8; Zinc transporter ZIP8; ZIP-8; Zrt- and Irt-like protein 8
Gene Aliases: BIGM103; CDG2N; LZT-Hs6; PP3105; SLC39A8; ZIP8
UniProt ID: (Human) Q9C0K1
Entrez Gene ID: (Human) 64116
Molecular Function: transporter