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Invitrogen
SLC39A8 Polyclonal Antibody
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Product Details
PA5-21073
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
An 18 amino acid peptide near the carboxy terminus of human ZIP8.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is human spleen tissue lysate.
PA5-21073 can be used with blocking peptide PEP-1187.
Target Information
The zinc transporter ZIP8, also known as SLC39A9, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP8 is glycosylated and located at the plasma membrane and mitochondria. It has been identified as the transporter responsible for transport of the toxic Cadmium cation. ZIP8 has also been suggested to play a role in the regulation of interferon-gamma expression in activated human T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BCG induced integral membrane protein BIGM103; BCG-induced integral membrane protein in monocyte clone 103 protein; LIV-1 subfamily of ZIP zinc transporter 6; LZT-Hs6; Metal cation symporter ZIP8; solute carrier family 39 (metal ion transporter), member 8; Solute carrier family 39 member 8; unnamed protein product; Zinc transporter 8; zinc transporter ZIP8; ZIP-8; Zrt- and Irt-like protein 8; ZRT/IRT-like protein 8
Gene Aliases: BIGM103; CDG2N; LZT-Hs6; PP3105; SLC39A8; ZIP8
UniProt ID: (Human) Q9C0K1
Entrez Gene ID: (Human) 64116
transcription, DNA-templated
regulation of transcription, DNA-templated
protein N-linked glycosylation
arginine metabolic process
ion transport
cobalt ion transport
zinc II ion transport
cellular zinc ion homeostasis
mercury ion transport
bicarbonate transport
metal ion transport
cellular cation homeostasis
cellular manganese ion homeostasis
extracellular matrix organization
regulation of membrane potential
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of inflammatory response
transmembrane transport
leukocyte adhesion to arterial endothelial cell
cadmium ion transmembrane transport
manganese ion transmembrane transport
zinc II ion transmembrane transport
zinc II ion transmembrane import
plasma membrane selenite transport
iron ion import across plasma membrane
cellular detoxification of cadmium ion
cartilage homeostasis
mitochondrial manganese ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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