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Proteintech
SLC4A10 Polyclonal Antibody
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Product Details
27197-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SLC4A10 fusion protein Ag26102
Conjugate
Form
Liquid
Concentration
0.55 mg/mL
Amount
82.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: TRNDEEAVVD RGGTRSILKT HFEKEDLEGH RTLFIGVHVP LGGRKSHRRH RHRGHKHRKR DRERDSGLED GRESPSFDT
Target Information
Members of the SLC4 bicarbonate transporter family are involved in solute transport and pH homeostasis. NCBE (SLC4A10) is a member of the SLC4 family of bicarbonate transporters, several of which play important roles in intracellular-pH regulation and transepithelial HCO(3)(-) transport. The SLC4A10 gene, which is highly expressed in the mammalian brain, contains two known alternative splicing units, inserts A and B. SLC4A10 encodes a sodium bicarbonate transporter with a brain-restricted expression pattern. Slc4a10 knockout (KO) mice have collapsed brain ventricles and display an increased seizure threshold, while heterozygous deletions in man have been associated with idiopathic epilepsy and other neurological symptoms. Slc4a10 is a promising pharmacological target for the therapy of epilepsy or elevated intracranial pressure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: NBCN2; NCBE; SLC4A10; sodium bicarbonate cotransporter member 10 variant NBCn2-E'; sodium bicarbonate cotransporter NBCn2-E; Sodium-Driven Chloride Bicarbonate Exchanger; Solute carrier family 4 member 10; solute carrier family 4, sodium bicarbonate cotransporter-like, member 10; solute carrier family 4, sodium bicarbonate transporter, member 10; unnamed protein product
Gene Aliases: Kiaa4136; mKIAA4136; NBCN2; NCBE; SLC4A10
UniProt ID: (Human) Q6U841, (Mouse) Q5DTL9
Entrez Gene ID: (Human) 57282, (Mouse) 94229
inorganic anion exchanger activity
anion transmembrane transporter activity
sodium:bicarbonate symporter activity
bicarbonate transmembrane transporter activity
secondary active transmembrane transporter activity
symporter activity
antiporter activity
sodium,bicarbonate:chloride antiporter activity
transporter activity
anion:anion antiporter activity
secondary carrier transporter
ion transport
sodium ion transport
anion transport
chloride transport
regulation of pH
visual perception
response to light stimulus
post-embryonic development
bicarbonate transport
pyramidal neuron development
regulation of cellular pH
multicellular organism growth
locomotory exploration behavior
sodium ion transmembrane transport
regulation of short-term neuronal synaptic plasticity
brain morphogenesis
regulation of intracellular pH
transmembrane transport
anion transmembrane transport
hydrogen ion transmembrane transport
protein glycosylation
transport
inorganic anion transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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