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Proteintech
SLC4A4 Polyclonal Antibody
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Product Details
11885-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SLC4A4 Fusion Protein Ag2490 (25-354 aa encoded by BC030977)
Conjugate
Form
Liquid
Concentration
0.32 mg/mL
Amount
48 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LRVVQPMFN HSIFTSAVSP AAERIRFILG EEDDSPAPPQ LFTELDELLA VDGQEMEWKE TARWIKFEEK VEQGGERWSK PHVATLSLHS LFELRTCMEK GSIMLDREAS SLPQLVEMIV DHQIETGLLK PELKDKVTYT LLRKHRHQTK KSNLRSLADI GKTVSSASRM FTNPDNGSPA MTHRNLTSSS LNDISDKPEK DQLKNKFMKK LPRDAEASNV LVGEVDFLDT PFIAFVRLQQ AVMLGALTEV PVPTRFLFIL LGPKGKAKSY HEIGRAIATL MSDEVFHDIA YKAKDRHDLI AGIDEFLDEV IVLPPGEWDP AIRIEPPKSL P (25-354 aa encoded by BC030977)
Target Information
Slc4a4 encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Slc4a4 is an electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. Moreover, Slc4a4 may regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. Isoform 2: May have a higher activity than isoform 1. Mutations in the Slc4a4 gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for the Slc4a4 gene. Diseases associated with SLC4A4 include Renal Tubular Acidosis, Proximal, With Ocular Abnormalities and Proximal Renal Tubular Acidosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: electrogenic Na/bicarbonate cotransporter NBCe1-C; Electrogenic sodium bicarbonate cotransporter 1; electrogenic sodium bicarbonate cotransporter NBCe1 variant D; HNBC 1; kidney type Na+/HCO3- cotransporter; kNBC 1; kNBC1; Na(+)/HCO3(-) cotransporter; Na+:HCO3- cotransporter; Na+HCO3- cotransporter 4; NBC 1; NBC 2; NBC isoform; electrogenic; NBC-like protein; NBCE 1; OTTHUMP00000160355; OTTHUMP00000218884; OTTHUMP00000218885; pancreas sodium bicarbonate cotransporter; pancreatic sodium bicarbonate cotransporter; Sodium bicarbonate cotransporter; sodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney; sodium bicarbonate cotransporter, pancreas); solute carrier family 4 (anion exchanger), member 4; solute carrier family 4 (sodium bicarbonate cotransporter), member 4; Solute carrier family 4 member 4; solute carrier family 4, member 4; solute carrier family 4, sodium bicarbonate cotransporter, member 4; solute carrier family 4, sodium bicarbonate cotransporter, member 4, brain type; solute carrier family 4, sodium bicarbonate cotransporter, member 5
Gene Aliases: AI835705; HHNMC; HNBC1; KNBC; kNBC1; NBC; NBC1; NBC2; Nbc4; NBCE1; NBCe1-A; PNBC; PRTAO; Rnbc1; SLC4A4; SLC4A5
UniProt ID: (Human) Q9Y6R1, (Mouse) O88343, (Rat) Q9JI66
Entrez Gene ID: (Human) 8671, (Mouse) 54403, (Rat) 84484
ion transport
sodium ion transport
anion transport
inorganic anion transport
bicarbonate transport
sodium ion transmembrane transport
sodium ion export from cell
regulation of membrane potential
positive regulation of glycolytic process
regulation of intracellular pH
transmembrane transport
anion transmembrane transport
transport across blood-brain barrier
transport
regulation of pH
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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