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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 295 of Human SLC4A8|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-27880 targets SLC4A8 in WB applications and shows reactivity with Human samples.
The PA5-27880 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 295 of Human SLC4A8.
Mediates electroneutral sodium- and carbonate-dependent choride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
electroneutral Na(+)-driven Cl-HCO3 exchanger; electroneutral sodium bicarbonate exchanger 1; k-NBC3; Na+-driven Cl-HCO3 exchanger; NBC3; NDCBE; solute carrier family 4 member 8; solute carrier family 4, sodium bicarbonate cotransporter, member 8
KIAA0739; NBC; NBC3; NDCBE; NDCBE1; SLC4A8