This antibody detects endogenous protein at a molecular weight of 67 kDa.
Purity is >95% by SDS-PAGE.
GAD-65 and GAD-67, glutamate decarboxylases function to catalyze the production of GABA ( gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA R alpha1-6, GABAA R beta1-3, GABAA R gamma1-3, GABAA R delta, GABAA R epsilon, GABAA R-rho-1 and GABAA R-rho-2. The GABAB family is composed of GABAB R1 alpha and GABAB R1 beta. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GABA T-1; GABA T1; GABA transporter 1; GABA transporter protein; GABAT1; GABATR; GABT1; gamma-aminobutyric acid (GABA-A) transporter 1; GAT-1; GAT1; Sodium- and chloride-dependent GABA transporter 1; solute carrier family 6 (neurotransmitter transporter), member 1; solute carrier family 6 (neurotransmitter transporter, GABA), member 1; Solute carrier family 6 member 1
Gene Aliases: A730043E01; GABATHG; GABATR; Gabt; GABT1; GAT-1; GAT1; MAE; SLC6A1; XT-1; Xtrp1