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Invitrogen
SLC6A4 Polyclonal Antibody
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FIGURE: 1 / 2
SLC6A4 Antibody (PA5-143620) in WB
Western blot analysis of SLC6A4 in different tissue and cell lysates. Samples were incubated in SLC6A4 polyclonal antibody (Product # PA5-143620) using a dilution of 1:1,000 (green). Left: [1] protein standard, [2] rat brain caudate/putmen region, [3] rat brain striatum region and [4] mouse brain. The prominent band at ~68 kDa corresponds to SERT protein, and lower bands are likely are proteolytic products of SERT. Right: [5] protein standard, [6] non-transfected HEK293 cells and [7] HEK293 cells transfected with an expression construct co... View More
Product Details
PA5-143620
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KSITPETPTEIPCGDIRLNAV coupled to KLH
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
5mM sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
SERT is an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5 OCD1; 5-hydroxytryptamine (serotonin) transporter; 5HT transporter; 5HTT; HGNC:11050; hSERT; Na+/Cl- dependent serotonin transporter; OTTHUMP00000163633; serotonin transporter; serotonin transporter 1; SERT; Sodium-dependent serotonin transporter; Sodium-dependent serotonin transporter (5HT transporter) (5HTT); solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter); Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter); solute carrier family 6 (neurotransmitter transporter), member 4; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; Solute carrier family 6 member 4; solute carrier family 6, member 4; unnamed protein product
Gene Aliases: 5-HTT; 5-HTTLPR; 5HTT; AI323329; hSERT; HTT; OCD1; SERT; SERT1; SLC6A4
UniProt ID: (Bovine) Q9XT49, (Human) P31645, (Rat) P31652, (Mouse) Q60857
Entrez Gene ID: (Bovine) 282365, (Human) 6532, (Rat) 25553, (Mouse) 15567
serotonin:sodium symporter activity
monoamine transmembrane transporter activity
identical protein binding
metal ion binding
nitric-oxide synthase binding
actin filament binding
serotonin binding
integrin binding
cation channel activity
neurotransmitter transporter activity
protein binding
antiporter activity
syntaxin-1 binding
cocaine binding
sodium ion binding
serotonin transmembrane transporter activity
myosin binding
Rab GTPase binding
protein homodimerization activity
neurotransmitter:sodium symporter activity
symporter activity
primary active transporter
serotonin transport
response to toxic substance
positive regulation of gene expression
monoamine transport
social behavior
positive regulation of cell cycle
negative regulation of organ growth
brain morphogenesis
serotonin uptake
transmembrane transport
cellular response to organic substance
regulation of thalamus size
response to hypoxia
neurotransmitter transport
amino acid transport
response to nutrient
memory
circadian rhythm
response to xenobiotic stimulus
positive regulation of serotonin secretion
negative regulation of cerebellar granule cell precursor proliferation
negative regulation of synaptic transmission, dopaminergic
response to estradiol
sodium ion transmembrane transport
vasoconstriction
negative regulation of neuron differentiation
behavioral response to cocaine
enteric nervous system development
membrane depolarization
male mating behavior
platelet aggregation
cellular response to retinoic acid
cellular response to cGMP
neurotransmitter reuptake
conditioned place preference
brain development
locomotory behavior
response to organic substance
thalamus development
response to drug
sperm ejaculation
protein oligomerization
protein homooligomerization
transport
organic cation transport
ammonium transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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