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Invitrogen
SLC6A4 Polyclonal Antibody
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FIGURE: 1 / 7
SLC6A4 Antibody (PA5-80032) in IHC (P)
Immunohistochemistry (Paraffin) analysis of SLC6A4 in paraffin-embedded section of mouse brain tissue using SLC6A4 Polyclonal Antibody (Product # PA5-80032). Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. The tissue section was then incubated with the primary antibody at a 5 µg/mL dilution overnight at 4°... View More
Product Details
PA5-80032
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human SLC6A4.
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
0.01mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
AA sequence: DDTRHSIPATTTTLVAELHQGERETWGKK
Positive Control - WB: human SH-SY5Y whole cell, human U2OS whole cell, human SW620 whole cell, human Hela whole cell, rat brain tissue, rat C6 whole cell, mouse brain tissue, mouse Neuro-2a whole cell, human HepG2 whole cell, human CACO-2 whole cell, human A549 whole cell, rat testis tissue, mouse testis tissue. IHC: mouse brain tissue, rat brain tissue.
Target Information
SERT is an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 5 OCD1; 5-hydroxytryptamine (serotonin) transporter; 5HT transporter; 5HTT; HGNC:11050; hSERT; Na+/Cl- dependent serotonin transporter; OTTHUMP00000163633; serotonin transporter; serotonin transporter 1; SERT; Sodium-dependent serotonin transporter; Sodium-dependent serotonin transporter (5HT transporter) (5HTT); solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter); Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter); solute carrier family 6 (neurotransmitter transporter), member 4; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; Solute carrier family 6 member 4; solute carrier family 6, member 4; unnamed protein product
Gene Aliases: 5-HTT; 5-HTTLPR; 5HTT; AI323329; hSERT; HTT; OCD1; SERT; SERT1; SLC6A4
UniProt ID: (Human) P31645, (Rat) P31652, (Mouse) Q60857
Entrez Gene ID: (Human) 6532, (Rat) 25553, (Mouse) 15567
integrin binding
cation channel activity
neurotransmitter transporter activity
serotonin:sodium symporter activity
protein binding
monoamine transmembrane transporter activity
antiporter activity
syntaxin-1 binding
cocaine binding
sodium ion binding
identical protein binding
metal ion binding
nitric-oxide synthase binding
actin filament binding
serotonin binding
serotonin transmembrane transporter activity
myosin binding
Rab GTPase binding
protein homodimerization activity
neurotransmitter:sodium symporter activity
symporter activity
primary active transporter
response to hypoxia
neurotransmitter transport
serotonin transport
amino acid transport
response to nutrient
memory
circadian rhythm
response to xenobiotic stimulus
response to toxic substance
positive regulation of gene expression
positive regulation of serotonin secretion
monoamine transport
negative regulation of cerebellar granule cell precursor proliferation
negative regulation of synaptic transmission, dopaminergic
response to estradiol
sodium ion transmembrane transport
vasoconstriction
negative regulation of neuron differentiation
positive regulation of cell cycle
negative regulation of organ growth
behavioral response to cocaine
enteric nervous system development
brain morphogenesis
serotonin uptake
membrane depolarization
male mating behavior
platelet aggregation
cellular response to retinoic acid
cellular response to cGMP
regulation of thalamus size
neurotransmitter reuptake
conditioned place preference
brain development
locomotory behavior
response to organic substance
thalamus development
social behavior
response to drug
sperm ejaculation
protein oligomerization
protein homooligomerization
transmembrane transport
cellular response to organic substance
transport
organic cation transport
ammonium transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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