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Invitrogen

SLC6A4 Polyclonal Antibody

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View all (22) SLC6A4 antibodies

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SLC6A4 Polyclonal Antibody

Product Details

PA5-80032

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

2-5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human SLC6A4.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

0.01mg sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2747147

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

AA sequence: DDTRHSIPATTTTLVAELHQGERETWGKK

Positive Control - WB: human SH-SY5Y whole cell, human U2OS whole cell, human SW620 whole cell, human Hela whole cell, rat brain tissue, rat C6 whole cell, mouse brain tissue, mouse Neuro-2a whole cell, human HepG2 whole cell, human CACO-2 whole cell, human A549 whole cell, rat testis tissue, mouse testis tissue. IHC: mouse brain tissue, rat brain tissue.

Target Information

SERT is an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 5 OCD1; 5-hydroxytryptamine (serotonin) transporter; 5HT transporter; 5HTT; HGNC:11050; hSERT; Na+/Cl- dependent serotonin transporter; OTTHUMP00000163633; serotonin transporter; serotonin transporter 1; SERT; Sodium-dependent serotonin transporter; Sodium-dependent serotonin transporter (5HT transporter) (5HTT); solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter); Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter); solute carrier family 6 (neurotransmitter transporter), member 4; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; Solute carrier family 6 member 4; solute carrier family 6, member 4; unnamed protein product

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Gene Aliases: 5-HTT; 5-HTTLPR; 5HTT; AI323329; hSERT; HTT; OCD1; SERT; SERT1; SLC6A4

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UniProt ID: (Human) P31645, (Rat) P31652, (Mouse) Q60857

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Entrez Gene ID: (Human) 6532, (Rat) 25553, (Mouse) 15567

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Function(s)
integrin binding cation channel activity neurotransmitter transporter activity serotonin:sodium symporter activity protein binding monoamine transmembrane transporter activity antiporter activity syntaxin-1 binding cocaine binding sodium ion binding identical protein binding metal ion binding nitric-oxide synthase binding actin filament binding serotonin binding serotonin transmembrane transporter activity myosin binding Rab GTPase binding protein homodimerization activity neurotransmitter:sodium symporter activity symporter activity primary active transporter
Process(es)
response to hypoxia neurotransmitter transport serotonin transport amino acid transport response to nutrient memory circadian rhythm response to xenobiotic stimulus response to toxic substance positive regulation of gene expression positive regulation of serotonin secretion monoamine transport negative regulation of cerebellar granule cell precursor proliferation negative regulation of synaptic transmission, dopaminergic response to estradiol sodium ion transmembrane transport vasoconstriction negative regulation of neuron differentiation positive regulation of cell cycle negative regulation of organ growth behavioral response to cocaine enteric nervous system development brain morphogenesis serotonin uptake membrane depolarization male mating behavior platelet aggregation cellular response to retinoic acid cellular response to cGMP regulation of thalamus size neurotransmitter reuptake conditioned place preference brain development locomotory behavior response to organic substance thalamus development social behavior response to drug sperm ejaculation protein oligomerization protein homooligomerization transmembrane transport cellular response to organic substance transport organic cation transport ammonium transmembrane transport
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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