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Invitrogen
SLC6A4 Polyclonal Antibody
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FIGURE: 1 / 2
SLC6A4 Antibody (PA5-89657) in IHC (P)
Immunohistochemistry analysis of SLC6A4 in paraffin-embedded human colon. Samples were incubated with SLC6A4 Polyclonal antibody (Product # PA5-89657) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-89657
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide
Conjugate
Form
Liquid
Concentration
0.46 mg/mL
Amount
46 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: U-251MG, Mouse lung; Cellular Location: Cell membrane, Endomembrane system, Endosome membrane, Multi-pass membrane protein
Immunogen sequence: METTPLNSQK QLSACEDGED CQENGVLQKV VPTPGDKVES GQISNGYSAV PSPGAGDDTR HSIPATTTTL VAELHQGERE TWGK
Target Information
SERT is an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5 OCD1; 5-hydroxytryptamine (serotonin) transporter; 5HT transporter; 5HTT; HGNC:11050; hSERT; Na+/Cl- dependent serotonin transporter; OTTHUMP00000163633; serotonin transporter; serotonin transporter 1; SERT; Sodium-dependent serotonin transporter; Sodium-dependent serotonin transporter (5HT transporter) (5HTT); solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter); Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter); solute carrier family 6 (neurotransmitter transporter), member 4; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; Solute carrier family 6 member 4; solute carrier family 6, member 4; unnamed protein product
Gene Aliases: 5-HTT; 5-HTTLPR; 5HTT; AI323329; hSERT; HTT; OCD1; SERT; SERT1; SLC6A4
UniProt ID: (Human) P31645, (Rat) P31652, (Mouse) Q60857
Entrez Gene ID: (Human) 6532, (Rat) 25553, (Mouse) 15567
integrin binding
cation channel activity
neurotransmitter transporter activity
serotonin:sodium symporter activity
protein binding
monoamine transmembrane transporter activity
antiporter activity
syntaxin-1 binding
cocaine binding
sodium ion binding
identical protein binding
metal ion binding
nitric-oxide synthase binding
actin filament binding
serotonin binding
serotonin transmembrane transporter activity
myosin binding
Rab GTPase binding
protein homodimerization activity
neurotransmitter:sodium symporter activity
symporter activity
primary active transporter
response to hypoxia
neurotransmitter transport
serotonin transport
amino acid transport
response to nutrient
memory
circadian rhythm
response to xenobiotic stimulus
response to toxic substance
positive regulation of gene expression
positive regulation of serotonin secretion
monoamine transport
negative regulation of cerebellar granule cell precursor proliferation
negative regulation of synaptic transmission, dopaminergic
response to estradiol
sodium ion transmembrane transport
vasoconstriction
negative regulation of neuron differentiation
positive regulation of cell cycle
negative regulation of organ growth
behavioral response to cocaine
enteric nervous system development
brain morphogenesis
serotonin uptake
membrane depolarization
male mating behavior
platelet aggregation
cellular response to retinoic acid
cellular response to cGMP
regulation of thalamus size
neurotransmitter reuptake
conditioned place preference
brain development
locomotory behavior
response to organic substance
thalamus development
social behavior
response to drug
sperm ejaculation
protein oligomerization
protein homooligomerization
transmembrane transport
cellular response to organic substance
transport
organic cation transport
ammonium transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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