Immunogen sequence: AVLTVALIEA VAVSWFYGIT QFCRDVKEML GFSPGWFWRI CWVAISPLFL LFIICSFLMS PPQLRLFQYN YPYWSIILGY CIGTSSFICI PTYIAYRLII TPGTFKERII KSITPETPTE IPCGDIRLNA V; Positive Samples: U-251MG, Mouse lung; Cellular Location: Cell membrane, Endomembrane system, Endosome membrane, Multi-pass membrane protein
SERT is an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.
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Protein Aliases: 5-hydroxytryptamine (serotonin) transporter; 5HT transporter; 5HTT; Na+/Cl- dependent serotonin transporter; serotonin transporter 1; SERT; Sodium-dependent serotonin transporter; Sodium-dependent serotonin transporter (5HT transporter) (5HTT); solute carrier family 6 (neurotransmitter transporter), member 4; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; Solute carrier family 6 member 4
Gene Aliases: 5-HTT; 5-HTTLPR; 5HTT; AI323329; hSERT; HTT; OCD1; SERT; SERT1; SLC6A4