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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:1,000 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
SLC6A8 Fusion Protein Ag14110 (541-635 aa encoded by BC012355) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.31 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.1% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: YYEPLVYNN TYVYPWWGEA MGWAFALSSM LCVPLHLLGC LLRAKGTMAE RWQHLTQPIW GLHHLEYRAQ DADVRGLTTL TPVSESSKVV VVESVM (541-635 aa encoded by BC012355)
SLC6A8 (solute carrier family 6 member 8), also known as CT1 (creatine transporter 1), CRT or CRTR, is a 635 amino acid multi-pass plasma membrane protein that belongs to the sodium/neurotransporter (SNF) family. Expressed in a variety of tissues including kidney, skeletal muscle, heart, brain, prostate, testis and colon, SLC6A8 functions to transport creatine into and out of cells, specifically those found in brain and muscle tissue. Creatine, an organic acid, occurs naturally and is essential for supplying the energy needed for proper muscle and nerve function. Defects in the gene encoding SLC6A8 lead to cerebral creatine deficiency and are the cause of X-linked creatine deficiency syndrome, a rare disorder characterized by facial anomalies, seizures and mental retardation. Multiple isoforms of SLC6A8 exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: creatine transporter 1; creatine transporter SLC6A8 variant D; CT1; MGC87396; Sodium- and chloride-dependent creatine transporter 1; solute carrier family 6 (neurotransmitter transporter), member 8; solute carrier family 6 (neurotransmitter transporter, creatine), member 8; Solute carrier family 6 member 8
Gene Aliases: CCDS1; CRT; CRTR; CT1; CTR5; SLC6A8
UniProt ID: (Human) P48029
Entrez Gene ID: (Human) 6535
Molecular Function:
primary active transporter
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