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Invitrogen
SLC7A5 Polyclonal Antibody
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Product Details
PA5-91842
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-125 of human LAT1/SLC7A5 (NP_0034774)
Conjugate
Form
Liquid
Concentration
0.93 mg/mL
Amount
93 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MAGAGPKRRA LAAPAAEEKE EAREKMLAAK SADGSAPAGE GEGVTLQRNI TLLNGVAIIV GTIIGSGIFV TPTGVLKEAG SPGLALVVWA ACGVFSIVGA LCYAELGTTI SKSGGDYAYM LEVYG; Positive Samples: A-549, MCF7, SW480, HeLa, HepG2, Mouse brain, Rat liver; Cellular Location: Apical cell membrane, Cytoplasm, Multi-pass membrane protein, cytosol
Target Information
Solute carrier family 7 member 5 also known as large neutral amino acids transporter small subunit 1 is a protein that in humans is encoded by the SLC7A5 gene.It is sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc.It involved in cellular amino acid uptake and the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta.Acts as an amino acid exchanger and plays a role in neuronal cell proliferation (neurogenesis) in brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 4F2; 4F2 LC; 4F2 light chain; 4F2HC; 4F2LC; 4T2HC; CD98 light chain; CD98HC; E16; hLAT1; Integral membrane protein E16; L-type amino acid transporter 1; Large neutral amino acids transporter small subunit 1; LAT-1; LAT1; MDU1; MP hLAT1; NACAE; Protein TA1; sodium-independent neutral amino acid transporter LAT1; solute carrier family 7 (amino acid transporter light chain, L system), member 5; solute carrier family 7 (cationic amino acid transporter, y+ system), member 5; Solute carrier family 7 member 5; tumor-associated protein 1; y+ system cationic amino acid transporter
Gene Aliases: 4F2LC; CD98; CD98LC; D0H16S474E; D16S469E; E16; LAT1; MPE16; SLC7A5; TA1
UniProt ID: (Human) Q01650, (Mouse) Q9Z127, (Rat) Q63016
Entrez Gene ID: (Human) 8140, (Mouse) 20539, (Rat) 50719
protein binding
amino acid transmembrane transporter activity
aromatic amino acid transmembrane transporter activity
neutral amino acid transmembrane transporter activity
L-amino acid transmembrane transporter activity
L-leucine transmembrane transporter activity
L-tryptophan transmembrane transporter activity
antiporter activity
thyroid hormone transmembrane transporter activity
transmembrane transporter activity
peptide antigen binding
L-phenylalanine transmembrane transporter activity
transporter
positive regulation of cytokine production involved in immune response
amino acid transmembrane transport
amino acid transport
negative regulation of autophagy
negative regulation of gene expression
response to muscle activity
neutral amino acid transport
L-amino acid transport
isoleucine transport
leucine transport
methionine transport
phenylalanine transport
proline transport
tryptophan transport
tyrosine transport
valine transport
alanine transport
positive regulation of interferon-gamma production
positive regulation of interleukin-17 production
positive regulation of interleukin-4 production
cellular response to glucose starvation
xenobiotic transport
transmembrane transport
response to hyperoxia
positive regulation of glial cell proliferation
thyroid hormone transport
cellular response to lipopolysaccharide
cellular response to amino acid stimulus
amino acid import across plasma membrane
liver regeneration
transport across blood-brain barrier
L-histidine transport
L-alpha-amino acid transmembrane transport
cellular response to L-arginine
L-leucine import across plasma membrane
L-tryptophan transmembrane transport
negative regulation of vascular associated smooth muscle cell apoptotic process
positive regulation of leucine import across plasma membrane
transport
multicellular organism development
nervous system development
cell differentiation
cation transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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