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SLC8A1 Polyclonal Antibody
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Product Details
OSS00316W-500UG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 420-470 of human SLC8A1 conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
5 mg/mL
Amount
500 µg
Purification
Affinity chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat and mouse.
Specificity of this antibody: SLC8A1.
Target Information
Ca2+ plays a critical role in intracellular signaling and thus regulation of calcium balance is critical for the maintenance of this signaling function. The plasma membrane Na+/Ca2+ (NaCX) exchangers mediate Na+-dependent Ca2+ efflux in a wide variety of cell types. NaCX can move Ca2+ either into or out of cells, depending on the net Na+, Ca2+, and K+ gradient across the membrane. In mammals, at least 5 distinct genes code for the exchangers: Three NaCX (NaCX-1, NaCX-2, and NaCX-3), and two in the NaCKX family (NaCKX-1 and NaCKX-2). NaCX-1 is most prominently expressed in the heart where it plays a major role in excitation-contraction coupling (Matsuoka et al., 1993). NACX-1 may also be a target for protection of the heart and brain from ischemia and reperfusion injury (Hagihara et al., 2005; Bano et al., 2005; Choi, 2005).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: isoform NCX1.3; isoform NCX1.7; Na(+)/Ca(2+)-exchange protein 1; Na+/Ca++ exchanger; Na+/Ca2+ exchanger; Na-Ca exchanger; Na/Ca exchanger; ncx1; Sodium/calcium exchanger 1; sodium/calcium exchanger isoform NaCa7; solute carrier family 8 (sodium/calcium exchanger), member 1; Solute carrier family 8 member 1; solute carrier family 8, member 1; unnamed protein product
Gene Aliases: AI852629; AV344025; CNC; D930008O12Rik; Ncx; NCX1; SLC8A1
UniProt ID: (Human) P32418, (Mouse) P70414, (Rat) Q01728
Entrez Gene ID: (Human) 6546, (Mouse) 20541, (Rat) 29715
calcium:sodium antiporter activity
calcium ion binding
protein binding
calmodulin binding
cytoskeletal protein binding
antiporter activity
ankyrin binding
ion channel binding
metal ion binding
calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential
secondary carrier transporter
regulation of the force of heart contraction
regulation of heart rate
ion transport
sodium ion transport
calcium ion transport
cellular calcium ion homeostasis
cellular sodium ion homeostasis
muscle contraction
cell communication
regulation of gene expression
regulation of cell communication by electrical coupling
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of cardiac muscle contraction by calcium ion signaling
vascular smooth muscle contraction
positive regulation of bone mineralization
cellular response to reactive oxygen species
sodium ion transmembrane transport
response to muscle stretch
sodium ion export from cell
relaxation of smooth muscle
negative regulation of cytosolic calcium ion concentration
cardiac muscle cell development
calcium ion homeostasis
transmembrane transport
relaxation of cardiac muscle
cardiac muscle contraction
calcium ion transport into cytosol
calcium ion import
calcium ion transmembrane transport
cellular response to caffeine
membrane depolarization during cardiac muscle cell action potential
cell communication by electrical coupling involved in cardiac conduction
calcium ion transmembrane import into cytosol
calcium ion import across plasma membrane
sodium ion import across plasma membrane
positive regulation of the force of heart contraction
calcium ion export
negative regulation of intracellular signal transduction
regulation of cardiac conduction
response to hypoxia
embryonic placenta development
regulation of sodium ion transport
heart morphogenesis
transport
positive regulation of cytosolic calcium ion concentration
post-embryonic development
positive regulation of fibroblast migration
response to ATP
embryonic heart tube development
muscle fiber development
regulation of calcium ion transport
cellular response to cAMP
sodium ion export
regulation of cardiac muscle cell membrane potential
sodium ion import
response to nutrient
response to glucose
telencephalon development
response to immobilization stress
response to drug
response to hydrogen peroxide
cellular response to hypoxia
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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