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Bioss
SLC8A2 Polyclonal Antibody
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Product Details
BS-1997R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human SLC8A2, amino acids 601-700.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Sodium/calcium exchanger proteins are integral membrane proteins primarily seen in cardiac cells. In cardiac myocytes, the concentration of Ca2+ alternates between low levels during relaxation and high levels during contraction. The Na+/Ca2+ exchanger 1 (NCX1) protein mediates Ca2+ extrusion from cardiac cells during relaxation. Four NCX1 isoforms (NCX1.1, NCX1.3, NCX1.7, and NCX1.10) result from alternate splicing. NCX1 mRNA is present at high levels in the heart, with lower levels present in the brain. NCX2 is most abundantly expressed in brain, in contrast the the broader distribution of NCX1, which is also expressed in heart, kidney, lung, smooth and skeletal muscle. The difference in expression for the transporter subtypes is believed to reflect differences in their functional roles. Regulation mechanisms for these exchanger proteins have not been fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Na(+)/Ca(2+)-exchange protein 2; Na+/Ca2+-exchanging protein Nac2; sodium-calcium exchanger 2; Sodium/calcium exchanger 2; solute carrier family 8 (sodium-calcium exchanger), member 2; solute carrier family 8 (sodium/calcium exchanger), member 2; Solute carrier family 8 member 2
Gene Aliases: KIAA1087; NCX2; SLC8A2
UniProt ID: (Human) Q9UPR5, (Rat) P48768, (Mouse) Q8K596
Entrez Gene ID: (Human) 6543, (Rat) 140447, (Mouse) 110891
ion transport
cellular calcium ion homeostasis
cell communication
learning
memory
sodium ion transmembrane transport
regulation of short-term neuronal synaptic plasticity
long-term synaptic potentiation
calcium ion transmembrane transport
regulation of cardiac conduction
sodium ion transport
calcium ion transport
telencephalon development
response to vitamin D
calcium ion transport into cytosol
calcium ion export from cell
calcium ion import into cell
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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