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Invitrogen
SLC8A2 Polyclonal Antibody
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Product Details
PA5-50558
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a region derived from internal residues of human solute carrier family 8 (sodium/calcium exchanger), member 2
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
40 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects endogenous levels of total SLC8A2 protein.
Target Information
Sodium/calcium exchanger proteins are integral membrane proteins primarily seen in cardiac cells. In cardiac myocytes, the concentration of Ca2+ alternates between low levels during relaxation and high levels during contraction. The Na+/Ca2+ exchanger 1 (NCX1) protein mediates Ca2+ extrusion from cardiac cells during relaxation. Four NCX1 isoforms (NCX1.1, NCX1.3, NCX1.7, and NCX1.10) result from alternate splicing. NCX1 mRNA is present at high levels in the heart, with lower levels present in the brain. NCX2 is most abundantly expressed in brain, in contrast the the broader distribution of NCX1, which is also expressed in heart, kidney, lung, smooth and skeletal muscle. The difference in expression for the transporter subtypes is believed to reflect differences in their functional roles. Regulation mechanisms for these exchanger proteins have not been fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Na(+)/Ca(2+)-exchange protein 2; Na+/Ca2+-exchanging protein Nac2; Sodium/calcium exchanger 2; solute carrier family 8 (sodium/calcium exchanger), member 2; Solute carrier family 8 member 2; unnamed protein product
Gene Aliases: KIAA1087; NCX2; SLC8A2
UniProt ID: (Human) Q9UPR5
Entrez Gene ID: (Human) 6543
response to ischemia
ion transport
sodium ion transport
calcium ion transport
cellular calcium ion homeostasis
cell communication
learning or memory
learning
memory
regulation of gene expression
sodium ion transmembrane transport
regulation of short-term neuronal synaptic plasticity
synapse organization
cognition
regulation of cytosolic calcium ion concentration
transmembrane transport
long-term synaptic potentiation
neuron cellular homeostasis
calcium ion transmembrane transport
calcium ion import across plasma membrane
modulation of excitatory postsynaptic potential
regulation of postsynaptic cytosolic calcium ion concentration
regulation of action potential firing pattern
regulation of calcineurin-mediated signaling
transport across blood-brain barrier
positive regulation of intracellular signal transduction
regulation of cardiac conduction
calcium ion export from cell
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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