This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: PANDSDTSTG GCQGSYRCQP GVLLPVWEPD DPSLGDKAA
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 95%.
Sodium/calcium exchanger proteins are integral membrane proteins primarily seen in cardiac cells. In cardiac myocytes, the concentration of Ca2+ alternates between low levels during relaxation and high levels during contraction. The Na+/Ca2+ exchanger 1 (NCX1) protein mediates Ca2+ extrusion from cardiac cells during relaxation. Four NCX1 isoforms (NCX1.1, NCX1.3, NCX1.7, and NCX1.10) result from alternate splicing. NCX1 mRNA is present at high levels in the heart, with lower levels present in the brain. NCX2 is most abundantly expressed in brain, in contrast the the broader distribution of NCX1, which is also expressed in heart, kidney, lung, smooth and skeletal muscle. The difference in expression for the transporter subtypes is believed to reflect differences in their functional roles. Regulation mechanisms for these exchanger proteins have not been fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Na(+)/Ca(2+)-exchange protein 2; Na+/Ca2+-exchanging protein Nac2; sodium-calcium exchanger 2; Sodium/calcium exchanger 2; solute carrier family 8 (sodium-calcium exchanger), member 2; solute carrier family 8 (sodium/calcium exchanger), member 2; Solute carrier family 8 member 2
Gene Aliases: KIAA1087; NCX2; SLC8A2
UniProt ID: (Human) Q9UPR5
Entrez Gene ID: (Human) 6543
Molecular Function: secondary carrier transporter