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Invitrogen
SLC8A2 Polyclonal Antibody
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FIGURE: 1 / 3
SLC8A2 Antibody (PA5-77563) in IHC (F)
Immunohistochemistry analysis of SLC8A2 in immersion-fixed, free floating, frozen rat brain. A) Samples were probed with SLC8A2 polyclonal antibody (Product # PA5-77563) using a dilution of 1:100, and incubated with DAPI (red). B) Stained cerebellar layers (blue). C) Merged image of Panels A and B.
Product Details
PA5-77563
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide (C)RVGDAQGMFEPDGG, corresponding to amino acid residues 486-499 of rat NCX-2
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Amount
40 µg
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
Product Specific Information
Product is shipped at room temperature as a lyophilized powder and should be stored at -20C upon receipt.
Reconstitute in 50 µL deionized water.
Target Information
Sodium/calcium exchanger proteins are integral membrane proteins primarily seen in cardiac cells. In cardiac myocytes, the concentration of Ca2+ alternates between low levels during relaxation and high levels during contraction. The Na+/Ca2+ exchanger 1 (NCX1) protein mediates Ca2+ extrusion from cardiac cells during relaxation. Four NCX1 isoforms (NCX1.1, NCX1.3, NCX1.7, and NCX1.10) result from alternate splicing. NCX1 mRNA is present at high levels in the heart, with lower levels present in the brain. NCX2 is most abundantly expressed in brain, in contrast the the broader distribution of NCX1, which is also expressed in heart, kidney, lung, smooth and skeletal muscle. The difference in expression for the transporter subtypes is believed to reflect differences in their functional roles. Regulation mechanisms for these exchanger proteins have not been fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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