Na+/H+ exchangers-1-6 (Na+/H+ antiporters, NHE-1-6) are integral membrane proteins that are expressed in most mammalian tissues, where they regulate intracellular pH and cell volume. NHEs mediate the secondary active extrusion of hydrogen (H+) ions out of cells in exchange for extracellular sodium (Na+). Excluding NHE-1, which is ubiquitously expressed, NHE isoforms 2-6 have distinct tissue- and cell type-dependent expression and inhibitiory characteristics by amiloride analogs. Human NHE-5 transcript (solute carrier family 9, isoform-5, SLC9A5) is an 896 amino acid protein that is expressed in brain, testis, spleen and skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Na(+)/H(+) exchanger 5; NHE-5; Sodium/hydrogen exchanger 5; solute carrier family 9 (sodium/hydrogen exchanger), isoform 5; solute carrier family 9 (sodium/hydrogen exchanger), member 5; Solute carrier family 9 member 5; solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
Gene Aliases: Gm696; NHE5; SLC9A5