Immunogen sequence: GHVLSSTGLT LPSMPSRNSV AETSVTNLLR ESGSGACLDL QVIDTVRSGR DREDAVMHHL LCGGLYKPRR RYKASCSRHF ISEDAQERQD KEVFQQNMKR RL
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 99%.
Na+/H+ exchangers-1-6 (Na+/H+ antiporters, NHE-1-6) are integral membrane proteins that are expressed in most mammalian tissues, where they regulate intracellular pH and cell volume. NHEs mediate the secondary active extrusion of hydrogen (H+) ions out of cells in exchange for extracellular sodium (Na+). Excluding NHE-1, which is ubiquitously expressed, NHE isoforms 2-6 have distinct tissue- and cell type-dependent expression and inhibitiory characteristics by amiloride analogs. Human NHE-5 transcript (solute carrier family 9, isoform-5, SLC9A5) is an 896 amino acid protein that is expressed in brain, testis, spleen and skeletal muscle.
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Protein Aliases: Na(+)/H(+) exchanger 5; NHE-5; Sodium/hydrogen exchanger 5; solute carrier family 9 (sodium/hydrogen exchanger), isoform 5; solute carrier family 9 (sodium/hydrogen exchanger), member 5; Solute carrier family 9 member 5; solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
Gene Aliases: NHE5; SLC9A5
UniProt ID: (Human) Q14940
Entrez Gene ID: (Human) 6553