Immunogen sequence: GGTTAMLSCL HIRVGVDSDQ EHLGVPENER RTTKAESAW
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.
Na+/H+ exchangers-1-6 (Na+/H+ antiporters, NHE-1-6) are integral membrane proteins that are expressed in most mammalian tissues where they regulate intracellular pH and cell volume. NHEs mediate the secondary active extrusion of hydrogen (H+) ions out of cells in exchange for extracellular sodium (Na+). Excluding NHE-1, which is ubiquitously expressed, the NHE isoforms 2-6 have distinct tissue- and cell type-dependent expression, and inhibitiory characteristics by amiloride analogs.
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Protein Aliases: Na(+)/H(+) exchanger 6; NHE-6; Sodium/hydrogen exchanger 6; solute carrier family 9 (sodium/hydrogen exchanger), member 6; Solute carrier family 9 member 6; solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
Gene Aliases: KIAA0267; MRSA; NHE6; SLC9A6
UniProt ID: (Human) Q92581
Entrez Gene ID: (Human) 10479