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Invitrogen
SLFN12 Polyclonal Antibody
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FIGURE: 1 / 1
SLFN12 Antibody (PA5-116929) in WB
Western blot analysis of SLFN12 in extracts of SH-SY5Y cells. Samples were incubated with SLFN12 Polyclonal antibody (Product # PA5-116929) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3s.
Product Details
PA5-116929
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 320-390 of human SLFN12 (NP_0012759381)
Conjugate
Form
Liquid
Concentration
1.08 mg/mL
Amount
108 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: SH-SY5Y
Immunogen sequence: DSWHVKDNRV MQLTRKEWIQ FMVEAEPKFS SSYEEVISQI NTSLPAPHSW PLLEWQRQRH HCPGLSGRIT Y
Target Information
Despite being first described several years ago, the roles of the Schlafen (SLFN) family of proteins remain largely unknown. The SLFN genes are preferentially expressed in lymphoid tissues and differentially regulated during thymocyte maturation. It is thought that many play roles in cell growth, hemopoietic cell differentiation, and T cell development and maturation. Most members contain at least one divergent AAA domain (AAA_4) that may play a role in ATP binding. Although also known as SLFN3, a Schlafen family member that may be a marker of T cell activation, human SLFN12 has relatively low homology to SLFN3 in other species. Loss of the SLFN12 gene due to deletion is associated with Kabuki syndrome, a multiple congenital anomaly syndrome, suggesting SLFN may play a role in this genetic condition.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ribonuclease SLFN12; Schlafen family member 12; unnamed protein product
Gene Aliases: SLFN12; SLFN3
UniProt ID: (Human) Q8IYM2
Entrez Gene ID: (Human) 55106
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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