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Invitrogen

SLIT2 Polyclonal Antibody

2 Published Figures
4 References
View all (14) SLIT2 antibodies

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Product Details

PA5-31133

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:10,000
View 1 publication 1 publication

Immunohistochemistry (IHC)

-
View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

ChIP assay (ChIP)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human SLIT2. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.41 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 1% BSA, 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2548607

Product Specific Information

Recommended positive controls: IMR32, SK-N-AS, mouse brain, rat brain, SLIT2-transfected 293T.

Predicted reactivity: Mouse (98%), Rat (95%), Zebrafish (88%), Xenopus laevis (93%), Chicken (97%), Bovine (99%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

SLIT2 are ligands for Robo receptors and play a vital role for axonal migration/navigation during neural development. A number of cleavage products through alternate splicing are reported in the literature for SLIT2 proteins. The C-terminal cleavage proteins are more diffusible than the larger N-terminal protein that is more tightly cell associated. SLIT2 protein is expressed in tissues such as fetal lung, kidney, and adult spinal cord.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: downregulated during adipocyte differentiation-1; neurogenic extracellular slit protein; Slit homolog 2 protein; Slit-2

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Gene Aliases: Drad-1; E030015M03Rik; E130320P19Rik; mKIAA4141; SLIL3; Slit-2; SLIT2

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UniProt ID: (Human) O94813, (Mouse) Q9R1B9

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Entrez Gene ID: (Human) 9353, (Rat) 360272, (Mouse) 20563

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Function(s)
GTPase inhibitor activity calcium ion binding protein binding heparin binding identical protein binding protein homodimerization activity laminin-1 binding proteoglycan binding heparan sulfate proteoglycan binding Roundabout binding follicle-stimulating hormone receptor activity chemorepellent activity receptor binding immunoglobulin superfamily cell adhesion molecule
Process(es)
ureteric bud development negative regulation of protein phosphorylation cell migration involved in sprouting angiogenesis negative regulation of leukocyte chemotaxis axon guidance motor neuron axon guidance negative regulation of lamellipodium assembly negative regulation of endothelial cell migration negative regulation of smooth muscle cell migration spinal cord development chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration chemorepulsion involved in postnatal olfactory bulb interneuron migration corticospinal neuron axon guidance through spinal cord negative regulation of cell growth negative regulation of cell migration negative regulation of actin filament polymerization retinal ganglion cell axon guidance response to nutrient levels cellular response to hormone stimulus negative regulation of GTPase activity Roundabout signaling pathway positive regulation of apoptotic process negative regulation of vascular permeability branching morphogenesis of an epithelial tube axon extension involved in axon guidance negative regulation of inflammatory response positive regulation of axonogenesis negative chemotaxis induction of negative chemotaxis negative regulation of small GTPase mediated signal transduction response to cortisol apoptotic process involved in luteolysis negative regulation of chemokine-mediated signaling pathway cellular response to heparin negative regulation of smooth muscle cell chemotaxis negative regulation of mononuclear cell migration negative regulation of neutrophil chemotaxis negative regulation of monocyte chemotaxis negative regulation of retinal ganglion cell axon guidance negative regulation of cellular response to growth factor stimulus metanephros development in utero embryonic development chemotaxis axonogenesis brain development negative regulation of cell proliferation negative regulation of gene expression single organismal cell-cell adhesion olfactory bulb development telencephalon cell migration cell differentiation negative regulation of axon extension dorsal/ventral axon guidance follicle-stimulating hormone signaling pathway negative regulation of catalytic activity neuron projection morphogenesis mammary gland duct morphogenesis mammary duct terminal end bud growth multicellular organism development nervous system development
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