PA5-31133 targets SLIT2 in WB applications and shows reactivity with Human and mouse samples.
The PA5-31133 immunogen is recombinant fragment corresponding to a region within amino acids 285 and 608 of Human SLIT2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Slit homolog 2 proteins (SLIT2) are ligands for the Roundabout (Robo) receptors and act as molecule guidance cues in cell migration. Slit1 and Slit2 are essential for midline guidance in the forebrain by acting as repulsive signals preventing inappropriate midline crossing by axons projecting from the olfactory bulb. Slit2 protein is expressed in fetal lung and kidney, and adult spinal cord. Weak expression is also noticed in adult adrenal gland, thyroid, and trachea. SLIT2 is a target for repression by EZH2 and is up-regulated in prostate cancer.
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Protein Aliases: downregulated during adipocyte differentiation-1; neurogenic extracellular slit protein; SLIL3; Slit homolog 2 protein; Slit homolog 2 protein C-product; Slit homolog 2 protein N-product; Slit-2
Gene Aliases: Drad-1; E030015M03Rik; E130320P19Rik; mKIAA4141; SLIL3; Slit-2; SLIT2