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Invitrogen
SLIT2 Polyclonal Antibody
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Product Details
PA5-82813
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SLIT2. Recombinant protein control fragment (Product #RP-92304).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LYINSELQDF QKVPMQTGIL PGCEPCHKKV CAHGTCQPSS QAGFTCECQE GWMGPLCDQR TNDPCLGNKC VHGTCLPINA FSYSCKCLE
Highest antigen sequence indentity to the following orthologs: Rat - 97%, Mouse - 94%.
Target Information
SLIT2 are ligands for Robo receptors and play a vital role for axonal migration/navigation during neural development. A number of cleavage products through alternate splicing are reported in the literature for SLIT2 proteins. The C-terminal cleavage proteins are more diffusible than the larger N-terminal protein that is more tightly cell associated. SLIT2 protein is expressed in tissues such as fetal lung, kidney, and adult spinal cord.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Slit homolog 2 protein; Slit-2
Gene Aliases: SLIL3; Slit-2; SLIT2
UniProt ID: (Human) O94813
Entrez Gene ID: (Human) 9353
ureteric bud development
negative regulation of protein phosphorylation
cell migration involved in sprouting angiogenesis
negative regulation of leukocyte chemotaxis
axon guidance
motor neuron axon guidance
negative regulation of lamellipodium assembly
negative regulation of endothelial cell migration
negative regulation of smooth muscle cell migration
spinal cord development
chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration
chemorepulsion involved in postnatal olfactory bulb interneuron migration
corticospinal neuron axon guidance through spinal cord
negative regulation of cell growth
negative regulation of cell migration
negative regulation of actin filament polymerization
retinal ganglion cell axon guidance
response to nutrient levels
cellular response to hormone stimulus
negative regulation of GTPase activity
Roundabout signaling pathway
positive regulation of apoptotic process
negative regulation of vascular permeability
branching morphogenesis of an epithelial tube
axon extension involved in axon guidance
negative regulation of inflammatory response
positive regulation of axonogenesis
negative chemotaxis
induction of negative chemotaxis
negative regulation of small GTPase mediated signal transduction
response to cortisol
apoptotic process involved in luteolysis
negative regulation of chemokine-mediated signaling pathway
cellular response to heparin
negative regulation of smooth muscle cell chemotaxis
negative regulation of mononuclear cell migration
negative regulation of neutrophil chemotaxis
negative regulation of monocyte chemotaxis
negative regulation of retinal ganglion cell axon guidance
negative regulation of cellular response to growth factor stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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