SLIT2 are ligands for Robo receptors and play a vital role for axonal migration/navigation during neural development. A number of cleavage products through alternate splicing are reported in the literature for SLIT2 proteins. The C-terminal cleavage proteins are more diffusible than the larger N-terminal protein that is more tightly cell associated. SLIT2 protein is expressed in tissues such as fetal lung, kidney, and adult spinal cord.
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Protein Aliases: downregulated during adipocyte differentiation-1; neurogenic extracellular slit protein; Slit homolog 2 protein; Slit homolog 2 protein C-product; Slit homolog 2 protein N-product; Slit-2
Gene Aliases: Drad-1; E030015M03Rik; E130320P19Rik; mKIAA4141; SLIL3; Slit-2; SLIT2
Molecular Function: immunoglobulin superfamily cell adhesion molecule