In Western blot, this antibody detects a band at ~30kDa in 293 cell lysate.
This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects.
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Protein Aliases: MGC10182; Neural crest transcription factor Slug; Protein snail homolog 2; SLUG; slug (chicken homolog), zinc finger protein; slug, chicken homolog; SLUGH1; snail family zinc finger 2; snail homolog 2; WS2D; Zinc finger protein SNAI2
Gene Aliases: SLUG; SLUGH; SLUGH1; SNAI2; SNAIL2; WS2D