This antibody is predicted to react with bovine, mouse and rat based on sequence homology.
SLUG is a member of the Snail family of C2H2-type zinc finger transcription factors. This protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in the gene encoding SLUG may be associated with sporadic cases of neural tube defects.
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Protein Aliases: Neural crest transcription factor Slug; Protein snail homolog 2; slug (chicken homolog), zinc finger protein; SNAI2; snail family zinc finger 2; Snail homolog 2; Zinc finger protein SLUG; Zinc finger protein SNAI2
Gene Aliases: SLUG; SLUGH; SLUGH1; SNAI2; SNAIL2; WS2D
UniProt ID: (Human) O43623
Entrez Gene ID: (Human) 6591