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Invitrogen
SLUG Polyclonal Antibody
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Product Details
PA5-20290
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 13 amino acid peptide from near the center of human Slug.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is 293 cell lysate.
PA5-20290 can be used with blocking peptide PEP-0420.
Target Information
Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemopoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MGC10182; Neural crest transcription factor Slug; Protein snail homolog 2; slug (chicken homolog), zinc finger protein; slug, chicken homolog; snail family zinc finger 2; snail homolog 2; Zinc finger protein SNAI2
Gene Aliases: SLUG; SLUGH; SLUGH1; SNAI2; SNAIL2; WS2D
UniProt ID: (Human) O43623, (Mouse) P97469
Entrez Gene ID: (Human) 6591, (Mouse) 20583
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
sequence-specific DNA binding
metal ion binding
nucleic acid binding
DNA binding
transcription factor activity, sequence-specific DNA binding
C2H2 zinc finger transcription factor
negative regulation of transcription from RNA polymerase II promoter
osteoblast differentiation
epithelial to mesenchymal transition
epithelial to mesenchymal transition involved in endocardial cushion formation
cell migration involved in endocardial cushion formation
transcription, DNA-templated
negative regulation of cell adhesion involved in substrate-bound cell migration
Notch signaling pathway
sensory perception of sound
negative regulation of keratinocyte proliferation
negative regulation of vitamin D biosynthetic process
neural crest cell development
positive regulation of cell migration
negative regulation of chondrocyte differentiation
regulation of chemokine production
negative regulation of cell adhesion mediated by integrin
positive regulation of histone acetylation
negative regulation of catenin import into nucleus
desmosome disassembly
pigmentation
negative regulation of DNA damage response, signal transduction by p53 class mediator
cellular response to fibroblast growth factor stimulus
positive regulation of fat cell differentiation
regulation of osteoblast differentiation
white fat cell differentiation
palate development
canonical Wnt signaling pathway
epithelium development
cartilage morphogenesis
regulation of branching involved in salivary gland morphogenesis
negative regulation of vitamin D receptor signaling pathway
cellular response to epidermal growth factor stimulus
cellular response to ionizing radiation
negative regulation of canonical Wnt signaling pathway
negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of stem cell proliferation
regulation of bicellular tight junction assembly
negative regulation of anoikis
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
multicellular organism development
response to radiation
cell migration
cellular response to platelet-derived growth factor stimulus
regulation of apoptotic process
negative regulation of apoptotic process
wound healing, spreading of cells
positive regulation of endothelial cell chemotaxis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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