FIGURE: 1 / 2
Immunogen sequence: PGCLLRAHVI CLAEEFLQEE PGQLLPLEGQ CPCCEKSLLW GDLIWLCQMD TEKEVEDSEL EEAHWTDLLE T
Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 77%.
This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A4 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4) gene.
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Protein Aliases: GIY-YIG domain-containing protein 1; SLX1 homolog B; SLX1 structure-specific endonuclease subunit homolog B; SLX1A; SLX1B; Structure-specific endonuclease subunit SLX1
Gene Aliases: GIYD1; GIYD2; SLX1; SLX1A; SLX1B
UniProt ID: (Human) Q9BQ83
Entrez Gene ID: (Human) 79008
Molecular Function: endodeoxyribonuclease