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Proteintech
SLX4 Polyclonal Antibody
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Product Details
31867-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SLX4 fusion protein Ag36095
Conjugate
Form
Liquid
Concentration
600 µg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: MPSAGGAQKP EGLETPKGAN RKKNLPPKVP ITPMPQYSIM ETPVLKKELD RFGVRPLPKR QMVLKLKEIF QYTHQTLDSD SEDESQSSQP LLQAPHCQTL ASQTYKPSRA GVHAQQEATT GPGAHRPKGP AKTKGPRHQR KHHESITPPS RSPTKEAPPG LNDDAQIPAS QESVATSVDG SDSSLSSQSS SSCEFGAAFE SAGEEEGEGE VSASQAAVQA ADTDEALRCY IRSKPALYQK VLLYQPFELR ELQAELRQNG LRVSSRRLLD FLDTHCITFT TAATRREKLQ GRRRQPRGKK KVERN
Target Information
This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BTB (POZ) domain containing 12; BTB/POZ domain-containing protein 12; SLX4 structure-specific endonuclease subunit; SLX4 structure-specific endonuclease subunit homolog; Structure-specific endonuclease subunit SLX4
Gene Aliases: AI256635; AI426760; BTBD12; D16Bwg1016e; FANCP; KIAA1784; KIAA1987; MUS312; RGD1566009; SLX4
UniProt ID: (Human) Q8IY92, (Mouse) Q6P1D7
Entrez Gene ID: (Human) 84464, (Rat) 302953, (Mouse) 52864
double-strand break repair via homologous recombination
DNA replication
DNA repair
nucleotide-excision repair
DNA double-strand break processing involved in repair via single-strand annealing
interstrand cross-link repair
positive regulation of catalytic activity
response to intra-S DNA damage checkpoint signaling
t-circle formation
positive regulation of t-circle formation
DNA catabolic process, endonucleolytic
DNA recombination
cellular response to DNA damage stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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