SMAD1 belongs to the SMAD family of proteins, which are downstream effectors of the TGF beta/BMP signaling pathway. Members of the SMAD family transmit TGF- beta signals from the cell surface into the nucleus. Once in the nucleus, SMADs can target a variety of DNA binding proteins to regulate transcriptional responses. SMAD1 is a receptor-regulated SMAD in the cell to regulate a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation, and apoptosis.
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Protein Aliases: BSP-1; BSP1; Dwarfin-A; Dwf-A; JV4-1; MAD homolog 1; MAD, mothers against decapentaplegic homolog 1; Mad-related protein 1; Mad1; MADH1; MADR1; mMad1; Mothers against decapentaplegic homolog 1; Mothers against DPP homolog 1; Mothers-against-DPP-related 1; Mothers-against-DPP-related-1; SMAD 1; SMAD family member 1; SMAD, mothers against DPP homolog 1; TGF-beta signaling protein 1; Transforming growth factor- beta signaling protein-1; transforming growth factor-beta signaling protein 1; Transforming growth factor-beta-signaling protein 1
Gene Aliases: AI528653; BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1; Mlp1; MusMLP; SMAD1
Molecular Function: transcription factor